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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-5-7
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pubmed:abstractText |
(64)Cu-diacetyl-bis (N(4)-methylthiosemicarbazone) ((64)Cu-ATSM) is a potential imaging agent of hypoxic tumor for use with PET. Recent literature demonstrated that cancer cells expressing CD133, which is a frequently used marker for so-called cancer stem cells or cancer stem cell-like cells (collectively referred to here as CSCs), contribute to tumor's therapeutic resistance and metastasis ability. Culturing under hypoxia is also reported to enlarge the proportion of CD133(+) cells, which would indicate survival advantage of CD133(+) cells under hypoxia. Here, we investigated the relationships between (64)Cu-ATSM accumulation and existence of CD133(+) cells using mouse colon carcinoma (colon-26) tumor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AC133 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Copper Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorodeoxyglucose F18,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Organometallic Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Radioactive Tracers,
http://linkedlifedata.com/resource/pubmed/chemical/Thiosemicarbazones,
http://linkedlifedata.com/resource/pubmed/chemical/copper (II)...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1872-9614
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pubmed:author |
pubmed-author:AsaiTatsuyaT,
pubmed-author:FujibayashiYasuhisaY,
pubmed-author:FurukawaTakakoT,
pubmed-author:KiyonoYasushiY,
pubmed-author:MoriTetsuyaT,
pubmed-author:OhMyungmiM,
pubmed-author:OkazawaHidehikoH,
pubmed-author:WakiAtsuoA,
pubmed-author:WatanabeRyoR,
pubmed-author:WelchMichael JMJ,
pubmed-author:YoshiiHiroshiH,
pubmed-author:YoshiiYukieY
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pubmed:copyrightInfo |
(c) 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
395-404
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pubmed:meshHeading |
pubmed-meshheading:20447549-Animals,
pubmed-meshheading:20447549-Antigens, CD,
pubmed-meshheading:20447549-Biological Transport,
pubmed-meshheading:20447549-Cell Hypoxia,
pubmed-meshheading:20447549-Cell Line, Tumor,
pubmed-meshheading:20447549-Colonic Neoplasms,
pubmed-meshheading:20447549-Copper Radioisotopes,
pubmed-meshheading:20447549-Fluorodeoxyglucose F18,
pubmed-meshheading:20447549-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20447549-Glucose,
pubmed-meshheading:20447549-Glycoproteins,
pubmed-meshheading:20447549-Male,
pubmed-meshheading:20447549-Mice,
pubmed-meshheading:20447549-Neoplastic Stem Cells,
pubmed-meshheading:20447549-Organometallic Compounds,
pubmed-meshheading:20447549-Peptides,
pubmed-meshheading:20447549-Radioactive Tracers,
pubmed-meshheading:20447549-Thiosemicarbazones
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pubmed:year |
2010
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pubmed:articleTitle |
Copper-64-diacetyl-bis (N4-methylthiosemicarbazone) accumulates in rich regions of CD133+ highly tumorigenic cells in mouse colon carcinoma.
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pubmed:affiliation |
Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui 910-1193, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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