Linked Life Data

20442944

Source:http://linkedlifedata.com/resource/pubmed/id/20442944

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2010-5-26
pubmed:abstractText
Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)(2)Ru(2)(OO[intersection]OO)(2)](2+) (OO[intersection]OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru(6)(p-cymene)(6)(dobq)(3)(tpp)(2)](6+), with IC(50) values of 2.1 microM and 3.8 microM against A2780 and A2780cisR cells, respectively.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1477-9234
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
39
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5272-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Anticancer activity of opened arene ruthenium metalla-assemblies.
pubmed:affiliation
Institute of Chemistry, University of Neuchatel, 51 Ave de Bellevaux, CH-2000, Neuchatel, Switzerland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't