Linked Life Data

2044233

Source:http://linkedlifedata.com/resource/pubmed/id/2044233

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-7-15
pubmed:abstractText
The sera of 187 patients from across the leprosy spectrum were screened for the expression of the PR4 idiotype, which was first identified on a human hybridoma-derived monoclonal antibody from a patient with leprosy and found to react with the Mycobacterium leprae phenolic glycolipid and a variety of polynucleotides. Sixty per cent (51 out of 85) of patients with lepromatous leprosy (LL), 66% (33 out of 49) with borderline lepromatous (BL) disease, 47% (14 out of 30) with borderline tuberculoid (BT) leprosy, and 56% (13 out of 23) of tuberculoid (TT) patients were found to have significantly elevated titres of the PR4 idiotype in their sera compared with endemic controls, irrespective of the presence or absence of endemic malaria. Sera from 52 patients with tuberculosis were also screened as a control for mycobacterial infection. The PR4 idiotype was significantly elevated in 37% (19 out of 52) of these patients. No correlation between idiotype and serum immunoglobulins IgG and IgM was found, indicating that the concentrations of idiotype levels in sera were not merely a reflection of changes in serum immunoglobulin levels. It is hypothesized that the expression of the PR4 idiotype is due to certain germline genes preferentially expressed rather than being the result of polyclonal B cell activation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-2189237, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-2979617, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-3048272, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-3101370, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-3292409, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-3492514, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-3814197, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-561759, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-6751630, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-6982135, http://linkedlifedata.com/resource/pubmed/commentcorrection/2044233-7045222
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
522-6
pubmed:dateRevised
2010-8-25
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Expression of a common idiotype PR4 in the sera of patients with leprosy.
pubmed:affiliation
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, England.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't