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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-8-30
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pubmed:abstractText |
The proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18 are central players in the pathogenesis of inflammatory bowel disease (IBD). In response to a variety of microbial components and crystalline substances, both cytokines are processed via the caspase-1-activating multiprotein complex, the NLRP3 inflammasome. Here, the role of the NLRP3 inflammasome in experimental colitis induced by dextran sodium sulfate (DSS) was examined.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1468-3288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1192-9
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pubmed:meshHeading |
pubmed-meshheading:20442201-Animals,
pubmed-meshheading:20442201-Carrier Proteins,
pubmed-meshheading:20442201-Caspase 1,
pubmed-meshheading:20442201-Colitis,
pubmed-meshheading:20442201-Dextran Sulfate,
pubmed-meshheading:20442201-Disease Models, Animal,
pubmed-meshheading:20442201-Inflammatory Bowel Diseases,
pubmed-meshheading:20442201-Interleukin-1beta,
pubmed-meshheading:20442201-Lysosomes,
pubmed-meshheading:20442201-Macrophages,
pubmed-meshheading:20442201-Mice,
pubmed-meshheading:20442201-Mice, Inbred C57BL,
pubmed-meshheading:20442201-Mice, Knockout,
pubmed-meshheading:20442201-Reactive Oxygen Species,
pubmed-meshheading:20442201-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.
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pubmed:affiliation |
Medizinische Klinik Innenstadt, University of Munich, Ziemssenstr. 1, D-80336 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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