Linked Life Data

20441896

Source:http://linkedlifedata.com/resource/pubmed/id/20441896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2010-5-5
pubmed:abstractText
A chemometric approach was used to study the retention behaviour of glycerol, urea and glycerol carbonate in hydrophilic interaction liquid chromatography (HILIC). First, a simplex method was developed to optimize the sensitivity of an evaporative light scattering detector. A mixture design was then applied to model retention factors as a function of the mobile phase content in acetonitrile, water and methanol on three columns: Atlantis HILIC Silica, ZIC-HILIC and Monochrom diol. Atlantis HILIC Silica exhibits predominantly hydrophobic interactions, while retention on the other two columns is mainly ruled by hydrophilic interactions. Finally, a desirability function is applied on the resolution factors. The use of this function enables the compositions of eluent phases to be determined in order to achieve separation between the three chemicals. Monochrom diol proved to be the most efficient column.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1873-3573
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1281-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Interest of a chemometric approach in understanding the retention behaviour of three columns in hydrophilic interaction liquid chromatography: application to the separation of glycerol carbonate, glycerol and urea.
pubmed:affiliation
ICOA - Université d'Orléans - CNRS - UMR 6005, Institut Universitaire de Technologie, BP 16729, 16 rue d'Issoudun, Orléans Cedex 2, France.
pubmed:publicationType
Journal Article