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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1991-7-12
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pubmed:databankReference |
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pubmed:abstractText |
The Dictyostelium ecmB gene encodes an extracellular matrix protein and is inducible by the stalk cell morphogen DIF. It is expressed in a subset of prestalk (pstB) cells in the slug and surrounding pstA cells first express it at culmination. A region of the ecmB promoter can direct transcription in all anterior prestalk cells, but a separate, downstream region acts to prevent its expression in pstA cells prior to culmination. This may be the site of interaction of a repressor, regulated by an extracellular antagonist to DIF. At culmination, expression of the ecmB gene also becomes greatly elevated in anterior-like cells as they move to surround the spore mass. A distal region of the ecmB promoter directs increased expression in those anterior-like cells that surmount the spore head. This divergence in gene expression suggests that anterior-like cells and anterior prestalk cells experience different inductive conditions at culmination.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
65
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pubmed:geneSymbol |
ecmB
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
983-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:2044155-Base Sequence,
pubmed-meshheading:2044155-Cell Differentiation,
pubmed-meshheading:2044155-DNA, Fungal,
pubmed-meshheading:2044155-DNA Mutational Analysis,
pubmed-meshheading:2044155-Dictyostelium,
pubmed-meshheading:2044155-Extracellular Matrix Proteins,
pubmed-meshheading:2044155-Fungal Proteins,
pubmed-meshheading:2044155-Gene Expression Regulation, Fungal,
pubmed-meshheading:2044155-Genes, Fungal,
pubmed-meshheading:2044155-Molecular Sequence Data,
pubmed-meshheading:2044155-Morphogenesis,
pubmed-meshheading:2044155-Promoter Regions, Genetic,
pubmed-meshheading:2044155-Protozoan Proteins,
pubmed-meshheading:2044155-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:2044155-Restriction Mapping
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pubmed:year |
1991
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pubmed:articleTitle |
Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in Dictyostelium.
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pubmed:affiliation |
Imperial Cancer Research Fund, Clare Hall Laboratories, Potters Bar, Hertfordshire, England.
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pubmed:publicationType |
Journal Article
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