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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-4
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pubmed:abstractText |
Adenoviruses can cause severe toxicity in children and in immunocompromised adults, and therefore a means to abrogate replication would be useful. With regard to cancer treatment, replication competent oncolytic adenoviruses have been safe in humans, although their efficacy has been variable. Therefore, more effective agents are now entering clinical testing and, consequently, replication-associated side effects remain a concern. Preclinical analysis of replication related toxicity has been hampered by a lack of permissive models. Therefore, it has been difficult to study modulation of human adenovirus replication in immune competent animals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1521-2254
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
435-45
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pubmed:meshHeading |
pubmed-meshheading:20440754-Adenoviridae Infections,
pubmed-meshheading:20440754-Adenoviruses, Human,
pubmed-meshheading:20440754-Animals,
pubmed-meshheading:20440754-Biological Transport,
pubmed-meshheading:20440754-Cell Death,
pubmed-meshheading:20440754-Cell Line,
pubmed-meshheading:20440754-Cell Line, Tumor,
pubmed-meshheading:20440754-Cell Nucleus,
pubmed-meshheading:20440754-Chlorpromazine,
pubmed-meshheading:20440754-Cricetinae,
pubmed-meshheading:20440754-Cytarabine,
pubmed-meshheading:20440754-Cytosine,
pubmed-meshheading:20440754-Humans,
pubmed-meshheading:20440754-Immunocompetence,
pubmed-meshheading:20440754-Mesocricetus,
pubmed-meshheading:20440754-Neoplasms,
pubmed-meshheading:20440754-Organ Specificity,
pubmed-meshheading:20440754-Phosphonic Acids,
pubmed-meshheading:20440754-Transduction, Genetic,
pubmed-meshheading:20440754-Virus Replication
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pubmed:year |
2010
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pubmed:articleTitle |
Human adenovirus replication in immunocompetent Syrian hamsters can be attenuated with chlorpromazine or cidofovir.
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pubmed:affiliation |
Cancer Gene Therapy Group, Molecular Cancer Biology Program & Transplantation Laboratory & Haartman Institute & Finnish Institute for Molecular Medicine, University of Helsinki, Haartmaninkatu 8, Helsinki, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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