Source:http://linkedlifedata.com/resource/pubmed/id/20440552
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-11-5
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| pubmed:abstractText |
Although many in vitro and animal studies have suggested a protective effect of green tea against breast cancer, findings from epidemiological studies have been inconsistent. No study has used prediagnostic biomarkers of tea polyphenols, which might play a protective role. A total of 24,226 women aged 40 to 69 years in the Japan Public Health Center-based Prospective Study who responded to the baseline questionnaire and provided blood in 1990-1995 were followed to December 2002. During a mean 10.6 years of follow-up, 144 newly diagnosed breast cancers were identified. Two matched controls for each case were selected from the cohort. Plasma levels of (-)-epigallocatechin (EGC), (-)-epicatechin (EC), (-)-epigallocatechin-3-gallate (EGCG), and (-)-epicatechin-3-gallate (ECG) were measured, and the odds ratio (OR) of breast cancer according to plasma level was estimated using a conditional logistic regression model. We found no statistically significant association between plasma tea polyphenol levels and breast cancer risk. Adjusted ORs for the highest versus lowest group were 0.90 (95% CI 0.42-1.96; P for trend = 0.98) for EGC, 0.95 (95% CI 0.43-2.08; P for trend = 0.86) for EC, 1.21 (95% CI 0.52-2.80; P for trend = 0.53) for EGCG, and 1.75 (95% CI 0.81-3.78; P for trend = 0.15) for ECG. Stratified analyses according to baseline menopausal status showed no remarkable difference between two strata. This nested case-control study found no overall association between plasma tea polyphenols and the risk of breast cancer in Japan.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catechin,
http://linkedlifedata.com/resource/pubmed/chemical/Flavonoids,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Polyphenols,
http://linkedlifedata.com/resource/pubmed/chemical/Tea,
http://linkedlifedata.com/resource/pubmed/chemical/epicatechin gallate,
http://linkedlifedata.com/resource/pubmed/chemical/epigallocatechin gallate,
http://linkedlifedata.com/resource/pubmed/chemical/gallocatechol
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1573-7217
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
124
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
827-34
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20440552-Adult,
pubmed-meshheading:20440552-Aged,
pubmed-meshheading:20440552-Asian Continental Ancestry Group,
pubmed-meshheading:20440552-Breast Neoplasms,
pubmed-meshheading:20440552-Case-Control Studies,
pubmed-meshheading:20440552-Catechin,
pubmed-meshheading:20440552-Female,
pubmed-meshheading:20440552-Flavonoids,
pubmed-meshheading:20440552-Humans,
pubmed-meshheading:20440552-Japan,
pubmed-meshheading:20440552-Logistic Models,
pubmed-meshheading:20440552-Middle Aged,
pubmed-meshheading:20440552-Odds Ratio,
pubmed-meshheading:20440552-Phenols,
pubmed-meshheading:20440552-Polyphenols,
pubmed-meshheading:20440552-Prospective Studies,
pubmed-meshheading:20440552-Questionnaires,
pubmed-meshheading:20440552-Risk Assessment,
pubmed-meshheading:20440552-Risk Factors,
pubmed-meshheading:20440552-Tea,
pubmed-meshheading:20440552-Time Factors
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| pubmed:year |
2010
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| pubmed:articleTitle |
Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case-control study.
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| pubmed:affiliation |
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo-ku, Tokyo, Japan. moiwasak@ncc.go.jp
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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