Linked Life Data

20439936

Source:http://linkedlifedata.com/resource/pubmed/id/20439936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-6-17
pubmed:abstractText
Genetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1544-0591
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
705-10
pubmed:meshHeading
pubmed-meshheading:20439936-Adenine, pubmed-meshheading:20439936-Adult, pubmed-meshheading:20439936-Age Factors, pubmed-meshheading:20439936-Alleles, pubmed-meshheading:20439936-Case-Control Studies, pubmed-meshheading:20439936-Chronic Periodontitis, pubmed-meshheading:20439936-Cytosine, pubmed-meshheading:20439936-Female, pubmed-meshheading:20439936-Genotype, pubmed-meshheading:20439936-Guanine, pubmed-meshheading:20439936-Haplotypes, pubmed-meshheading:20439936-Hong Kong, pubmed-meshheading:20439936-Humans, pubmed-meshheading:20439936-Male, pubmed-meshheading:20439936-Middle Aged, pubmed-meshheading:20439936-Polymorphism, Single Nucleotide, pubmed-meshheading:20439936-Receptors, IgG, pubmed-meshheading:20439936-Sex Factors, pubmed-meshheading:20439936-Smoking, pubmed-meshheading:20439936-Thymine
pubmed:year
2010
pubmed:articleTitle
SNPs of Fc-gamma receptor genes and chronic periodontitis.
pubmed:affiliation
Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't