Source:http://linkedlifedata.com/resource/pubmed/id/20439728
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
20
|
pubmed:dateCreated |
2010-5-20
|
pubmed:abstractText |
Several cytokines (including IL-2, IL-7, IL-15, and IL-21) that signal through receptors sharing the common gamma chain (gamma(c)) are critical for the generation and peripheral homeostasis of naive and memory T cells. Recently, we demonstrated that effector functions fail to develop in CD4(+) T cells that differentiate in the absence of gamma(c). To assess the role of gamma(c) cytokines in cell-fate decisions that condition effector versus memory CD8(+) T cell generation, we compared the response of CD8(+) T cells from gamma(c)(+) or gamma(c)(-) P14 TCR transgenic mice after challenge with lymphocytic choriomeningitis virus. The intrinsic IL-7-dependent survival defect of gamma(c)(-) naive CD8(+) T cells was corrected by transgenic expression of human Bcl-2. We demonstrated that although gamma(c)-dependent signals are dispensable for the initial expansion and the acquisition of cytotoxic functions following antigenic stimulation, they condition the terminal proliferation and differentiation of CD8(+) effector T cells (i.e., KLRG1(high) CD127(low) short-lived effector T cells) via the transcription factor, T-bet. Moreover, the gamma(c)-dependent signals that are critical for memory T cell formation are not rescued by Bcl2 overexpression. Together, these data reveal an unexpected divergence in the requirement for gamma(c) cytokines in the differentiation of CD4(+) versus CD8(+) cytotoxic T lymphocytes.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1091-6490
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:day |
18
|
pubmed:volume |
107
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
9311-6
|
pubmed:dateRevised |
2010-11-22
|
pubmed:meshHeading |
pubmed-meshheading:20439728-Animals,
pubmed-meshheading:20439728-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20439728-Cell Differentiation,
pubmed-meshheading:20439728-Flow Cytometry,
pubmed-meshheading:20439728-Humans,
pubmed-meshheading:20439728-Image Processing, Computer-Assisted,
pubmed-meshheading:20439728-Immunologic Memory,
pubmed-meshheading:20439728-Interleukin Receptor Common gamma Subunit,
pubmed-meshheading:20439728-Mice,
pubmed-meshheading:20439728-Mice, Transgenic,
pubmed-meshheading:20439728-Proto-Oncogene Proteins c-bcl-2
|
pubmed:year |
2010
|
pubmed:articleTitle |
Gamma(c) deficiency precludes CD8+ T cell memory despite formation of potent T cell effectors.
|
pubmed:affiliation |
Cytokines and Lymphocyte Development Unit, Institut Pasteur, Paris F-75015, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|