rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-5-24
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pubmed:abstractText |
The paramyxovirus F protein is a class I viral membrane fusion protein which undergoes a significant refolding transition during virus entry. Previous studies of the Newcastle disease virus, human parainfluenza virus 3 and parainfluenza virus 5 F proteins revealed differences in the pre- and post-fusion structures. The NDV Queensland (Q) F structure lacked structural elements observed in the other two structures, which are key to the refolding and fusogenic activity of F. Here we present the NDV Australia-Victoria (AV) F protein post-fusion structure and provide EM evidence for its folding to a pre-fusion form. The NDV AV F structure contains heptad repeat elements missing in the previous NDV Q F structure, forming a post-fusion six-helix bundle (6HB) similar to the post-fusion hPIV3 F structure. Electrostatic and temperature factor analysis of the F structures points to regions of these proteins that may be functionally important in their membrane fusion activity.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-10077567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-10198633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-10430879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-10814577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-11286892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-11483506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-11517324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-12393927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-12671653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-14581458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-14993666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-15299926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-15572765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-15964978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-16397490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-17093041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-17553889,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-17870467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-18568847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-8072525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-8072533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-9163431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-9689046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-9705252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-9844633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20439109-9927582
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1096-0341
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
5
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pubmed:volume |
402
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
372-9
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20439109-Crystallography, X-Ray,
pubmed-meshheading:20439109-Microscopy, Electron,
pubmed-meshheading:20439109-Models, Molecular,
pubmed-meshheading:20439109-Newcastle disease virus,
pubmed-meshheading:20439109-Protein Conformation,
pubmed-meshheading:20439109-Protein Folding,
pubmed-meshheading:20439109-Protein Structure, Tertiary,
pubmed-meshheading:20439109-Viral Fusion Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Structure of the Newcastle disease virus F protein in the post-fusion conformation.
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pubmed:affiliation |
Howard Hughes Medical Institute, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|