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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-3
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pubmed:abstractText |
Parkinson's disease (PD) has been associated with mild cognitive impairment (PDMCI) and with dementia (PDD). Using radial distance mapping, we studied the 3D structural and volumetric differences between the hippocampi, caudates, and lateral ventricles in 20 cognitively normal elderly (NC), 12 cognitively normal PD (PDND), 8 PDMCI, and 15 PDD subjects and examined the associations between these structures and Unified Parkinson's Disease Rating Scale (UPDRS) Part III:motor subscale and Mini-Mental State Examination (MMSE) performance. There were no hippocampal differences between the groups. 3D caudate statistical maps demonstrated significant left medial and lateral and right medial atrophy in the PDD vs. NC, and right medial and lateral caudate atrophy in PDD vs. PDND. PDMCI showed trend-level significant left lateral caudate atrophy vs. NC. Both left and right ventricles were significantly larger in PDD relative to the NC and PDND with posterior (body/occipital horn) predominance. The magnitude of regionally significant between-group differences in radial distance ranged between 20-30% for caudate and 5-20% for ventricles. UPDRS Part III:motor subscale score correlated with ventricular enlargement. MMSE showed significant correlation with expansion of the posterior lateral ventricles and trend-level significant correlation with caudate head atrophy. Cognitive decline in PD is associated with anterior caudate atrophy and ventricular enlargement.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1531-8257
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pubmed:author |
pubmed-author:AarslandDagD,
pubmed-author:ApostolovaLiana GLG,
pubmed-author:AvedissianChristinaC,
pubmed-author:BeyerMonaM,
pubmed-author:ChouYi-YuYY,
pubmed-author:CummingsJeffrey LJL,
pubmed-author:GreenAmity EAE,
pubmed-author:HwangKristy SKS,
pubmed-author:JanvinCarmen CCC,
pubmed-author:LarsenJan PJP,
pubmed-author:MorraJonathan HJH,
pubmed-author:ThompsonPaul MPM
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pubmed:copyrightInfo |
2010 Movement Disorder Society
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pubmed:issnType |
Electronic
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pubmed:day |
30
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
687-95
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:20437538-Aged,
pubmed-meshheading:20437538-Aged, 80 and over,
pubmed-meshheading:20437538-Analysis of Variance,
pubmed-meshheading:20437538-Brain Mapping,
pubmed-meshheading:20437538-Caudate Nucleus,
pubmed-meshheading:20437538-Cerebral Ventricles,
pubmed-meshheading:20437538-Dementia,
pubmed-meshheading:20437538-Female,
pubmed-meshheading:20437538-Hippocampus,
pubmed-meshheading:20437538-Humans,
pubmed-meshheading:20437538-Image Processing, Computer-Assisted,
pubmed-meshheading:20437538-Magnetic Resonance Imaging,
pubmed-meshheading:20437538-Male,
pubmed-meshheading:20437538-Parkinson Disease
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pubmed:year |
2010
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pubmed:articleTitle |
Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia.
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pubmed:affiliation |
Department of Neurology, David Geffen School of Medicine, UCLA, California, USA. lapostolova@mednet.ucla.edu
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