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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-3
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pubmed:abstractText |
In a rabbit model of collagenase-induced osteoarthritis, the additive effects of intra-articular recombinant human growth hormone (GH) administration to hyaluronic acid (HA) were evaluated. After intra-articular collagenase injection, mature New Zealand white rabbits (n=30) were divided into 3 groups. Group 1 (control rabbits) received once weekly intra-articular saline injections for 4 weeks. Group 2 rabbits received 6 mg HA injections, and group 3 rabbits were injected with 6 mg HA and 3 mg recombinant human GH. These injections were initiated 4 weeks after collagenase injections. Lameness was observed for 9 weeks after collagenase injections. Macroscopic and histopathological knee joint findings were also evaluated at the end of 9 weeks after collagenase injections. Although all animals had lameness after collagenase injections, the duration and severity of lameness were significantly shorter and less severe in group 3 than group 1 and 2 (P<0.01). Macroscopic scores showed that femoral condyles of group 3 rabbits received significantly less cartilage damage than those of groups 1 and 2 rabbits (P<0.01). Histopathological score was also the lowest in group 3 (P<0.01). These results suggest that co-injection of intra-articular HA and recombinant human GH is more effective than HA injections alone in an osteoarthritis model.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-10714616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-1123374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-1147021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-11969306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-12753861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-14555268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-1548262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-16574267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-16866972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-17135962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-17174116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-2242289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-5580011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-7174151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-7488273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-7543114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-8118990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-8689457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-8729484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-9143992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-9682784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20436717-9706425
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1598-6357
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
776-80
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20436717-Animals,
pubmed-meshheading:20436717-Collagenases,
pubmed-meshheading:20436717-Disease Models, Animal,
pubmed-meshheading:20436717-Drug Combinations,
pubmed-meshheading:20436717-Drug Synergism,
pubmed-meshheading:20436717-Human Growth Hormone,
pubmed-meshheading:20436717-Humans,
pubmed-meshheading:20436717-Hyaluronic Acid,
pubmed-meshheading:20436717-Injections, Intra-Articular,
pubmed-meshheading:20436717-Male,
pubmed-meshheading:20436717-Osteoarthritis,
pubmed-meshheading:20436717-Rabbits,
pubmed-meshheading:20436717-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Additive effects of intra-articular injection of growth hormone and hyaluronic acid in rabbit model of collagenase-induced osteoarthritis.
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pubmed:affiliation |
Department of Physical Medicine and Rehabilitation, Dong A University College of Medicine, Busan, Korea.
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pubmed:publicationType |
Journal Article
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