| pubmed-article:20434524 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0037929 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C1522384 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0458247 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
| pubmed-article:20434524 | lifeskim:mentions | umls-concept:C0458083 | lld:lifeskim |
| pubmed-article:20434524 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20434524 | pubmed:dateCreated | 2010-6-10 | lld:pubmed |
| pubmed-article:20434524 | pubmed:abstractText | The development of central neuropathic pain varies among patients with spinal cord injury (SCI). The factors contributing to the development and perpetuation of segmental pain (at-level allodynia) has been the focus of ongoing experiments in our laboratory. One such factor is hormonal status. We have shown previously, using a male rat model of SCI, that a severe contusion injury is necessary for the development of allodynia in trunk regions at and just above the level of a T8 injury. In this study, we examined at-level sensitivity for SCI ovariectomized (ovx) and cycling female rats as well as for SCI males implanted with either a placebo pellet or one that slowly releases 17beta-estradiol. The proportion of ovx SCI female rats and placebo-treated SCI males displaying pain-like behaviors to touch/pressure of at-level dermatomes up to 6 weeks post-injury (67% and 75%, respectively) was similar to our previous studies on SCI males (69%). In contrast, significantly fewer cycling SCI female rats and 17beta-estradiol treated SCI male rats showed sensitivity to touch at-level (26% and 30%, respectively). These results implicate 17beta-estradiol as a potential target that can readily be modulated to prevent segmental pain following SCI. | lld:pubmed |
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| pubmed-article:20434524 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20434524 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20434524 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20434524 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20434524 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20434524 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20434524 | pubmed:issn | 1872-7972 | lld:pubmed |
| pubmed-article:20434524 | pubmed:author | pubmed-author:HubscherCharl... | lld:pubmed |
| pubmed-article:20434524 | pubmed:author | pubmed-author:GuptaDaya SDS | lld:pubmed |
| pubmed-article:20434524 | pubmed:author | pubmed-author:FellJason DJD | lld:pubmed |
| pubmed-article:20434524 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ireland Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20434524 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20434524 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:20434524 | pubmed:volume | 477 | lld:pubmed |
| pubmed-article:20434524 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20434524 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20434524 | pubmed:pagination | 153-6 | lld:pubmed |
| pubmed-article:20434524 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:meshHeading | pubmed-meshheading:20434524... | lld:pubmed |
| pubmed-article:20434524 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20434524 | pubmed:articleTitle | Sex and hormonal variations in the development of at-level allodynia in a rat chronic spinal cord injury model. | lld:pubmed |
| pubmed-article:20434524 | pubmed:affiliation | Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY 40292, USA. chhubs01@louisville.edu | lld:pubmed |
| pubmed-article:20434524 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20434524 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
