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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-6-10
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pubmed:abstractText |
The development of central neuropathic pain varies among patients with spinal cord injury (SCI). The factors contributing to the development and perpetuation of segmental pain (at-level allodynia) has been the focus of ongoing experiments in our laboratory. One such factor is hormonal status. We have shown previously, using a male rat model of SCI, that a severe contusion injury is necessary for the development of allodynia in trunk regions at and just above the level of a T8 injury. In this study, we examined at-level sensitivity for SCI ovariectomized (ovx) and cycling female rats as well as for SCI males implanted with either a placebo pellet or one that slowly releases 17beta-estradiol. The proportion of ovx SCI female rats and placebo-treated SCI males displaying pain-like behaviors to touch/pressure of at-level dermatomes up to 6 weeks post-injury (67% and 75%, respectively) was similar to our previous studies on SCI males (69%). In contrast, significantly fewer cycling SCI female rats and 17beta-estradiol treated SCI male rats showed sensitivity to touch at-level (26% and 30%, respectively). These results implicate 17beta-estradiol as a potential target that can readily be modulated to prevent segmental pain following SCI.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1872-7972
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
477
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-6
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:20434524-Animals,
pubmed-meshheading:20434524-Chronic Disease,
pubmed-meshheading:20434524-Estradiol,
pubmed-meshheading:20434524-Estrus,
pubmed-meshheading:20434524-Female,
pubmed-meshheading:20434524-Hyperalgesia,
pubmed-meshheading:20434524-Male,
pubmed-meshheading:20434524-Ovariectomy,
pubmed-meshheading:20434524-Pressure,
pubmed-meshheading:20434524-Rats,
pubmed-meshheading:20434524-Rats, Wistar,
pubmed-meshheading:20434524-Sex Factors,
pubmed-meshheading:20434524-Spinal Cord Injuries,
pubmed-meshheading:20434524-Touch
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pubmed:year |
2010
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pubmed:articleTitle |
Sex and hormonal variations in the development of at-level allodynia in a rat chronic spinal cord injury model.
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pubmed:affiliation |
Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY 40292, USA. chhubs01@louisville.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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