rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-2-7
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pubmed:abstractText |
Previously, we demonstrated that inhibition of poly(ADP-ribose) polymerase (PARP) exerts protective effects against high-fat (HF) diet-induced atherogenesis in part by increasing tissue inhibitor of metalloproteinase (TIMP)-2 expression. Given that characteristics of dilated cardiomyopathy closely associate with atherosclerosis and are mediated by an imbalance between matrix metalloproteinases (MMPs) and TIMPs, we hypothesized that PARP-1 gene deletion may protect against HF-induced cardiac hypertrophy and dilatations by altering TIMP-2/MMPs balance in favor of a maintenance of tissue homeostasis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1879-1336
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pubmed:author |
pubmed-author:BoularesA HamidAH,
pubmed-author:FengYumeiY,
pubmed-author:HansChetan PCP,
pubmed-author:JuJihangJ,
pubmed-author:KayeAlan DAD,
pubmed-author:KimHogyoungH,
pubmed-author:LazartiguesEricE,
pubmed-author:MatrouguiKhalidK,
pubmed-author:NauraAmarjit SAS,
pubmed-author:SiddiquiDanishD,
pubmed-author:TroxclairDanaD,
pubmed-author:ZerfaouiMouradM
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pubmed:copyrightInfo |
Copyright © 2011 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e57-68
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:20434371-Animals,
pubmed-meshheading:20434371-Apoptosis,
pubmed-meshheading:20434371-Blotting, Western,
pubmed-meshheading:20434371-Cardiomyopathy, Dilated,
pubmed-meshheading:20434371-Cell Degranulation,
pubmed-meshheading:20434371-Diet, Atherogenic,
pubmed-meshheading:20434371-Dyslipidemias,
pubmed-meshheading:20434371-Immunohistochemistry,
pubmed-meshheading:20434371-In Situ Nick-End Labeling,
pubmed-meshheading:20434371-Mast Cells,
pubmed-meshheading:20434371-Matrix Metalloproteinase 9,
pubmed-meshheading:20434371-Mice,
pubmed-meshheading:20434371-Mice, Inbred C57BL,
pubmed-meshheading:20434371-Mice, Knockout,
pubmed-meshheading:20434371-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:20434371-Polymerase Chain Reaction,
pubmed-meshheading:20434371-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:20434371-Transfection
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pubmed:articleTitle |
Opposing roles of PARP-1 in MMP-9 and TIMP-2 expression and mast cell degranulation in dyslipidemic dilated cardiomyopathy.
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pubmed:affiliation |
Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA. chetan.hans@nationwidechildrens.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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