Chronic nonbacterial osteomyelitis (CNO) is an inflammatory disorder of unknown etiology. In children and adolescents CNO predominantly affects the metaphyses of the long bones, but lesions can occur at any site of the skeleton. Prospectively followed cohorts using a standardized protocol in diagnosis and treatment have rarely been reported.
Children's Hospital, Section of Paediatric Rheumatology, Osteology, Immunology and Infectious Diseases, University of Würzburg, Josef Schneider Strasse 2, 97080 Würzburg, Germany.
