| pubmed-article:20431622 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C0246120 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:20431622 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:20431622 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20431622 | pubmed:dateCreated | 2010-5-20 | lld:pubmed |
| pubmed-article:20431622 | pubmed:abstractText | CD4(+) helper T cells acquire effector phenotypes that promote specialized inflammatory responses. We show that the ETS-family transcription factor PU.1 was required for the development of an interleukin 9 (IL-9)-secreting subset of helper T cells. Decreasing PU.1 expression either by conditional deletion in mouse T cells or the use of small interfering RNA in human T cells impaired IL-9 production, whereas ectopic PU.1 expression promoted IL-9 production. Mice with PU.1-deficient T cells developed normal T helper type 2 (T(H)2) responses in vivo but showed attenuated allergic pulmonary inflammation that corresponded to lower expression of Il9 and chemokines in peripheral T cells and in lungs than that of wild-type mice. Together our data suggest a critical role for PU.1 in generating the IL-9-producing (T(H)9) phenotype and in the development of allergic inflammation. | lld:pubmed |
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| pubmed-article:20431622 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20431622 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20431622 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20431622 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20431622 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20431622 | pubmed:issn | 1529-2916 | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:HanLingL | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:RobertsonMich... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:NuttStephen... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:KaplanMark... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:YuQingQ | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:TepperRobert... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:ChangHua-Chen... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:SehraSaritaS | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:JabeenRukhsan... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:YaoWeiguoW | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:PerumalNaraya... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:StriteskyGret... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:NguyenEvelyn... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:GoswamiRitobr... | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:McKinleyCarlC | lld:pubmed |
| pubmed-article:20431622 | pubmed:author | pubmed-author:AhyiAyele-Nat... | lld:pubmed |
| pubmed-article:20431622 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20431622 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:20431622 | pubmed:owner | NLM | lld:pubmed |
