|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2010-5-20
|
|
pubmed:abstractText |
CD4(+) helper T cells acquire effector phenotypes that promote specialized inflammatory responses. We show that the ETS-family transcription factor PU.1 was required for the development of an interleukin 9 (IL-9)-secreting subset of helper T cells. Decreasing PU.1 expression either by conditional deletion in mouse T cells or the use of small interfering RNA in human T cells impaired IL-9 production, whereas ectopic PU.1 expression promoted IL-9 production. Mice with PU.1-deficient T cells developed normal T helper type 2 (T(H)2) responses in vivo but showed attenuated allergic pulmonary inflammation that corresponded to lower expression of Il9 and chemokines in peripheral T cells and in lungs than that of wild-type mice. Together our data suggest a critical role for PU.1 in generating the IL-9-producing (T(H)9) phenotype and in the development of allergic inflammation.
|
|
pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/R01 AI057459-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI057459-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI57459,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA118118,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA118118-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 CA118118-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL080071,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL080071-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL080071-05,
http://linkedlifedata.com/resource/pubmed/grant/T32 AI060519,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI070448,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI070448-04,
http://linkedlifedata.com/resource/pubmed/grant/U19 AI070448-05
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-10384142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-10629460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-11070175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-11160256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-11781348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-11781365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-12055627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-12153980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-12461566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-12789235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-15133304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-15183090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-15546393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-15867096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-15963784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-16551261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-16618596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-16782025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-16921386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-17101709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-17101734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-17195845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-17312173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-17676043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18378796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18408735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18760452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18931678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18941183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18993086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-18997793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19062085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19132915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19144320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19342650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19433802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19446146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19464987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19592658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19596803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-19801513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-20514670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-7930607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-9673269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20431622-9763610
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
1529-2916
|
|
pubmed:author |
pubmed-author:AhyiAyele-NatiAN,
pubmed-author:ChangHua-ChenHC,
pubmed-author:GoswamiRitobrataR,
pubmed-author:HanLingL,
pubmed-author:JabeenRukhsanaR,
pubmed-author:KaplanMark HMH,
pubmed-author:McKinleyCarlC,
pubmed-author:NguyenEvelyn TET,
pubmed-author:NuttStephen LSL,
pubmed-author:PerumalNarayanan BNB,
pubmed-author:RobertsonMichael JMJ,
pubmed-author:SehraSaritaS,
pubmed-author:StriteskyGretta LGL,
pubmed-author:TepperRobert SRS,
pubmed-author:YaoWeiguoW,
pubmed-author:YuQingQ
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
