Source:http://linkedlifedata.com/resource/pubmed/id/20430832
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
Pt 6
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| pubmed:dateCreated |
2010-5-31
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| pubmed:abstractText |
The histopathological hallmark of multiple system atrophy is the appearance of intracellular inclusion bodies, named glial cytoplasmic inclusions, which are mainly composed of alpha-synuclein fibrils. In vivo visualization of alpha-synuclein deposition should be used for the diagnosis and assessment of therapy and severity of pathological progression in multiple system atrophy. Because 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole could stain alpha-synuclein-containing glial cytoplasmic inclusions in post-mortem brains, we compared the carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography findings of eight multiple system atrophy cases to those of age-matched normal controls. The positron emission tomography data demonstrated high distribution volumes in the subcortical white matter (uncorrected P < 0.001), putamen and posterior cingulate cortex (uncorrected P < 0.005), globus pallidus, primary motor cortex and anterior cingulate cortex (uncorrected P < 0.01), and substantia nigra (uncorrected P < 0.05) in multiple system atrophy cases compared to the normal controls. They were coincident with glial cytoplasmic inclusion-rich brain areas in multiple system atrophy and thus, carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography is a promising surrogate marker for monitoring intracellular alpha-synuclein deposition in living brains.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-(2-(2-dimethylaminothiazol-5-yl)et...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Synuclein
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1460-2156
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| pubmed:author |
pubmed-author:AraiHiroyukiH,
pubmed-author:BabaToruT,
pubmed-author:FukudaHiroshiH,
pubmed-author:FunakiYoshihitoY,
pubmed-author:FurumotoShozoS,
pubmed-author:HasegawaTakafumiT,
pubmed-author:ItoyamaYasutoY,
pubmed-author:IwataRenR,
pubmed-author:KikuchiAkioA,
pubmed-author:KobayashiMichikoM,
pubmed-author:KudoYukitsukaY,
pubmed-author:MikiYasuoY,
pubmed-author:MoriFumiakiF,
pubmed-author:OkamuraNobuyukiN,
pubmed-author:SugenoNaotoN,
pubmed-author:TakahashiShokiS,
pubmed-author:TakedaAtsushiA,
pubmed-author:TashiroManabuM,
pubmed-author:WakabayashiKoichiK,
pubmed-author:YanaiKazuhikoK
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| pubmed:issnType |
Electronic
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| pubmed:volume |
133
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1772-8
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| pubmed:meshHeading |
pubmed-meshheading:20430832-Benzoxazoles,
pubmed-meshheading:20430832-Brain,
pubmed-meshheading:20430832-Carbon Radioisotopes,
pubmed-meshheading:20430832-Female,
pubmed-meshheading:20430832-Humans,
pubmed-meshheading:20430832-Immunohistochemistry,
pubmed-meshheading:20430832-Male,
pubmed-meshheading:20430832-Microscopy, Fluorescence,
pubmed-meshheading:20430832-Middle Aged,
pubmed-meshheading:20430832-Multiple System Atrophy,
pubmed-meshheading:20430832-Positron-Emission Tomography,
pubmed-meshheading:20430832-Thiazoles,
pubmed-meshheading:20430832-alpha-Synuclein
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| pubmed:year |
2010
|
| pubmed:articleTitle |
In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.
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| pubmed:affiliation |
Department of Neurology, Graduate School of Medicine, Tohoku University, Sendai, 980-8574 Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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