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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-25
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pubmed:abstractText |
Nephrogenic systemic fibrosis (NSF) is an uncommon fibrotic disorder occurring after administration of linear gadolinium contrast agents in patients with severely decreased kidney function. The underlying pathogenetic mechanism of fibrosis remains to be elucidated. Transforming growth factor beta (TGF-beta), a key player in the pathogenesis of fibrotic disorders, has been found to be overexpressed in NSF skin lesions. The aim of this study is to analyze the TGF-beta-SMAD-connective tissue growth factor (CTGF) axis in NSF skin lesions compared with skin specimens from patients with systemic sclerosis, hemodialysis patients without NSF, and healthy controls. Additionally, expression of tissue inhibitor of metalloproteinase 1 (TIMP-1) and antifibrotic tumor necrosis factor alpha (TNF-alpha) were examined.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1523-6838
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1040-9
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pubmed:dateRevised |
2010-8-2
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pubmed:meshHeading |
pubmed-meshheading:20430497-Aged,
pubmed-meshheading:20430497-Aged, 80 and over,
pubmed-meshheading:20430497-Biopsy,
pubmed-meshheading:20430497-Cohort Studies,
pubmed-meshheading:20430497-Connective Tissue Growth Factor,
pubmed-meshheading:20430497-Female,
pubmed-meshheading:20430497-Humans,
pubmed-meshheading:20430497-Kidney Diseases,
pubmed-meshheading:20430497-Male,
pubmed-meshheading:20430497-Middle Aged,
pubmed-meshheading:20430497-Nephrogenic Fibrosing Dermopathy,
pubmed-meshheading:20430497-RNA, Messenger,
pubmed-meshheading:20430497-Renal Dialysis,
pubmed-meshheading:20430497-Scleroderma, Systemic,
pubmed-meshheading:20430497-Signal Transduction,
pubmed-meshheading:20430497-Skin,
pubmed-meshheading:20430497-Smad2 Protein,
pubmed-meshheading:20430497-Smad3 Protein,
pubmed-meshheading:20430497-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:20430497-Transforming Growth Factor beta,
pubmed-meshheading:20430497-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Balance of profibrotic and antifibrotic [corrected] signaling in nephrogenic systemic fibrosis skin lesions.
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pubmed:affiliation |
Department of Nephrology, University Hospital, Heinrich-Heine University Düsseldorf, Germany. gisela.schieren@med.uni-duesseldorf.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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