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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1991-7-11
|
| pubmed:abstractText |
We examined the relationship of maturity-onset clinical diabetes mellitus with the subsequent incidence of coronary heart disease, stroke, total cardiovascular mortality, and all-cause mortality in a cohort of 116,177 US women who were 30 to 55 years of age and free of known coronary heart disease, stroke, and cancer in 1976. During 8 years of follow-up (889 255 person-years), we identified 338 nonfatal myocardial infarctions, 111 coronary deaths, 259 strokes, 238 cardiovascular deaths, and 1349 deaths from all causes. Diabetes was associated with a markedly increased risk of nonfatal myocardial infarction and fatal coronary heart disease (age-adjusted relative risk [RR] = 6.7; 95% confidence interval [CI], 5.3 to 8.4), ischemic stroke (RR = 5.4; 95% CI, 3.3 to 9.0), total cardiovascular mortality (RR = 6.3; 95% CI, 4.6 to 8.6), and all-cause mortality (RR = 3.0; 95% CI, 2.5 to 3.7). A major independent effect of diabetes persisted in multivariate analyses after simultaneous control for other known coronary risk factors (for these end points, RR [95% CI] = 3.1 [2.3 to 4.2], 3.0 [1.6 to 5.7], 3.0 [1.9 to 4.8], and 1.9 [1.4 to 2.4], respectively). The absolute excess coronary risk due to diabetes was greater in the presence of other risk factors, including cigarette smoking, hypertension, and obesity. These prospective data indicate that maturity-onset clinical diabetes is a strong determinant of coronary heart disease, ischemic stroke, and cardiovascular mortality among middle-aged women. The adverse effect of diabetes is amplified in the presence of other cardiovascular risk factors, many of which are modifiable.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0003-9926
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
151
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1141-7
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2043016-Adult,
pubmed-meshheading:2043016-Cardiovascular Diseases,
pubmed-meshheading:2043016-Cerebrovascular Disorders,
pubmed-meshheading:2043016-Coronary Disease,
pubmed-meshheading:2043016-Diabetes Mellitus, Type 2,
pubmed-meshheading:2043016-Diabetic Angiopathies,
pubmed-meshheading:2043016-Female,
pubmed-meshheading:2043016-Follow-Up Studies,
pubmed-meshheading:2043016-Humans,
pubmed-meshheading:2043016-Incidence,
pubmed-meshheading:2043016-Middle Aged,
pubmed-meshheading:2043016-Obesity,
pubmed-meshheading:2043016-Prevalence,
pubmed-meshheading:2043016-Prospective Studies,
pubmed-meshheading:2043016-Questionnaires,
pubmed-meshheading:2043016-Risk Factors,
pubmed-meshheading:2043016-Smoking,
pubmed-meshheading:2043016-Survival Rate
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women.
|
| pubmed:affiliation |
Channing Laboratory, Department of Medicine, Harvard Medical School, Boston, MA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|