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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
Mucosal leishmaniasis (ML) follows localized cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Proinflammatory responses mediate CL self-healing but are exaggerated in ML. Proinflammatory monocyte chemoattractant protein 1 (MCP-1; encoded by CCL2) is associated with CL. We explore its role in CL/ML through analysis of the regulatory CCL2 -2518bp promoter polymorphism in CL/ML population samples and families from Brazil. Genotype frequencies were compared among ML/CL cases and control groups using logistic regression and the family-based association test (FBAT). MCP-1 was measured in plasma and macrophages. The GG recessive genotype at CCL2 -2518bp was more common in patients with ML (N=67) than in neighborhood control (NC; N=60) subjects (OR 1.78; 95% CI 1.01-3.14; P=0.045), than in NC combined with leishmanin skin-test positive (N=60) controls (OR 4.40; 95% CI 1.42-13.65; P=0.010), and than in controls combined with CL (N=60) patients (OR 2.78; 95% CI 1.13-6.85; P=0.045). No associations were observed for CL compared to any groups. FBAT (91 ML and 223 CL cases in families) confirmed recessive association of ML with allele G (Z=2.679; P=0.007). Higher levels of MCP-1 occurred in plasma (P=0.03) and macrophages (P<0.0001) from GG compared to AA individuals. These results suggest that high MCP-1 increases risk of ML.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/,
http://linkedlifedata.com/resource/pubmed/grant/1 D43 TW007127-01,
http://linkedlifedata.com/resource/pubmed/grant/P50 AI-30639,
http://linkedlifedata.com/resource/pubmed/grant/P50 AI030639-18,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI048822-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI067874-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI076233-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AI076233-03,
http://linkedlifedata.com/resource/pubmed/grant/R01AI067874,
http://linkedlifedata.com/resource/pubmed/grant/R03 TW001369-03,
http://linkedlifedata.com/resource/pubmed/grant/R03AI070909
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-10362511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-11055368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-11093125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-11313775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-11719900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-12085314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-12374865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-12438348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-15322011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-16014836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-16113301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-16299275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-16352737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-16804844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-16845637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-17430548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-18424735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-18940815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-2063957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-2186747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-3232172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-4067312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-7595196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-8619444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-8627035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-9634505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20430117-9790427
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1567-7257
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pubmed:author |
pubmed-author:AlmeidaRoqueR,
pubmed-author:BlackwellJenefer MJM,
pubmed-author:CarvalhoEdgar MEM,
pubmed-author:CastellucciLéaL,
pubmed-author:GuimarãesLuiz HenriqueLH,
pubmed-author:JamiesonSarra ESE,
pubmed-author:KalilJorgeJ,
pubmed-author:LessaMarcusM,
pubmed-author:MagalhãesAndreaA,
pubmed-author:MenezesElianeE,
pubmed-author:NoronhaElzaE,
pubmed-author:OliveiraJoyceJ,
pubmed-author:RamasawmyRajendranathR,
pubmed-author:RosaMaria Elisa AME,
pubmed-author:WilsonMary EME,
pubmed-author:de JesusAmélia RibeiroAR
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pubmed:copyrightInfo |
Copyright 2010 Elsevier B.V. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
607-13
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pubmed:dateRevised |
2011-8-1
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pubmed:meshHeading |
pubmed-meshheading:20430117-Humans,
pubmed-meshheading:20430117-Animals,
pubmed-meshheading:20430117-Female,
pubmed-meshheading:20430117-Leishmaniasis, Cutaneous,
pubmed-meshheading:20430117-Male,
pubmed-meshheading:20430117-Brazil,
pubmed-meshheading:20430117-Adult,
pubmed-meshheading:20430117-Leishmaniasis, Mucocutaneous,
pubmed-meshheading:20430117-Middle Aged,
pubmed-meshheading:20430117-Gene Frequency,
pubmed-meshheading:20430117-Genotype,
pubmed-meshheading:20430117-Case-Control Studies,
pubmed-meshheading:20430117-Genetic Predisposition to Disease,
pubmed-meshheading:20430117-Promoter Regions, Genetic,
pubmed-meshheading:20430117-Cytokines,
pubmed-meshheading:20430117-Leishmania braziliensis,
pubmed-meshheading:20430117-Chemokine CCL2,
pubmed-meshheading:20430117-Polymorphism, Single Nucleotide,
pubmed-meshheading:20430117-Genetic Association Studies
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