Source:http://linkedlifedata.com/resource/pubmed/id/20428811
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-4-29
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| pubmed:abstractText |
The premalignant potential of Peutz-Jeghers syndrome (PJS) hamartomas has not been established. The major gene responsible for PJS is LKB1. LKB1 has a complex cellular role, therefore, the exact role of LKB1 in Peutz-Jeghers syndrome hamartomas (PJSs) is particularly difficult to understand. It has recently been found that LKB1 functions in the Wnt pathway in Xenopus during early development. Aberrant beta-catenin expression, the key regulator of the activated Wnt/beta-catenin signaling pathway, appears to stimulate interferon-induced gene 1 (IFITM1) products in intestinal tumorigenesis. Both contribute to intestinal tumor formation and tumor progression. This study was designed to investigate expression of LKB1, beta-catenin and IFITM1 in PJSs, colorectal adenomas (CRAs), colorectal carcinomas (CRCs) and normal colorectal mucosas (NCs) using RT-PCR and immunohistochemistry. Immunofluorescence was used to assess the co-expression characteristics of beta-catenin and IFITM1. Results showed that the expression profiles of LKB1, beta-catenin and IFITM1 in PJSs were similar to those in CRAs both at the mRNA and protein levels. The cytoplasmic level of beta-catenin expression correlated strongly with LKB1 and IFITM1 expression in the tumor cells. The dyregulation of beta-catenin was found in a majority (16/20) of the PJS polyps. Immunofluorescence also revealed co-expression of beta-catenin and IFITM1 in the cytoplasm of the PJSs. These findings suggest that Wnt signaling may be activated in a subset of PJSs, and activation of the Wnt/beta-catenin signaling in PJS polyps may be caused by LKB1 expression. The activated beta-catenin signaling pathway including IFITM1 might play an important role in a subset of PJS polyps.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/STK11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin,
http://linkedlifedata.com/resource/pubmed/chemical/leu-13 antigen
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1791-2431
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1569-76
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:20428811-Adenocarcinoma,
pubmed-meshheading:20428811-Adenoma,
pubmed-meshheading:20428811-Adolescent,
pubmed-meshheading:20428811-Adult,
pubmed-meshheading:20428811-Aged,
pubmed-meshheading:20428811-Antigens, Differentiation,
pubmed-meshheading:20428811-Blotting, Western,
pubmed-meshheading:20428811-Colon,
pubmed-meshheading:20428811-Colorectal Neoplasms,
pubmed-meshheading:20428811-Cytoplasm,
pubmed-meshheading:20428811-Female,
pubmed-meshheading:20428811-Fluorescent Antibody Technique,
pubmed-meshheading:20428811-Humans,
pubmed-meshheading:20428811-Immunoenzyme Techniques,
pubmed-meshheading:20428811-Male,
pubmed-meshheading:20428811-Membrane Proteins,
pubmed-meshheading:20428811-Middle Aged,
pubmed-meshheading:20428811-Peutz-Jeghers Syndrome,
pubmed-meshheading:20428811-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20428811-RNA, Messenger,
pubmed-meshheading:20428811-Rectum,
pubmed-meshheading:20428811-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20428811-Signal Transduction,
pubmed-meshheading:20428811-Young Adult,
pubmed-meshheading:20428811-beta Catenin
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| pubmed:year |
2010
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| pubmed:articleTitle |
Wnt signaling may be activated in a subset of Peutz-Jeghers syndrome polyps closely correlating to LKB1 expression.
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| pubmed:affiliation |
Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China.
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| pubmed:publicationType |
Journal Article
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