| pubmed-article:20427410 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C0024141 | lld:lifeskim |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C0599283 | lld:lifeskim |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C1518527 | lld:lifeskim |
| pubmed-article:20427410 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:20427410 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20427410 | pubmed:dateCreated | 2010-6-28 | lld:pubmed |
| pubmed-article:20427410 | pubmed:abstractText | Gamma-aminobutyric acid-A (GABA-A) receptors play a crucial role in regulating neuronal excitability and cognitive functions. Single-photon emission computerized tomography (SPECT) analysis of GABA-A receptors binding by (123)I-labelled Iomazenil ((123)I-IMZ) has been applied in some neuropsychiatric disorders to investigate conditions where GABA-A receptor density can be detected in several pathophysiological conditions. In this study we investigate cerebral GABA-A receptor density in a small series of patients with systemic lupus erythematosus (SLE) and cognitive impairment characterized by recurrent, episodic memory loss. Nine female patients with SLE and cognitive alterations underwent to a clinical neuropsychiatric evaluation including digital video-EEG, brain MRI, (99m)Tc-ECD brain SPECT and (123)I-IMZ brain SPECT. All patients tested showed diffuse or focal GABA-A receptor density reduction. This is, to our knowledge, the first report on GABA-A receptor density abnormalities associated with cognitive defects in SLE patients. We hypothesize that in our series a decrease in GABA-A receptor density might be related to the neurological manifestations. Further studies are needed to clarify this aspect and the possible mechanisms. GABA-A receptor density impairment might be due to the SLE-related cerebral vasculopathy, or to neuronal-reacting auto-antibodies or drugs which could interfere with GABA-A receptors expression/binding. This study may support the concept that cognitive impairment in systemic lupus erythematosus could be the outcome of fine-tuned neurotransmission alterations. | lld:pubmed |
| pubmed-article:20427410 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20427410 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20427410 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20427410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20427410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20427410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20427410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20427410 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20427410 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20427410 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20427410 | pubmed:issn | 1477-0962 | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:MathieuAA | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:SerraAA | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:MarrosuFF | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:SannaGG | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:VaccaAA | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:PorroAA | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:PigaMM | lld:pubmed |
| pubmed-article:20427410 | pubmed:author | pubmed-author:CauleEE | lld:pubmed |
| pubmed-article:20427410 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20427410 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:20427410 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20427410 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20427410 | pubmed:pagination | 918-26 | lld:pubmed |
| pubmed-article:20427410 | pubmed:dateRevised | 2011-3-11 | lld:pubmed |
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| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:meshHeading | pubmed-meshheading:20427410... | lld:pubmed |
| pubmed-article:20427410 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20427410 | pubmed:articleTitle | Defective cerebral gamma-aminobutyric acid-A receptor density in patients with systemic lupus erythematosus and central nervous system involvement. An observational study. | lld:pubmed |
| pubmed-article:20427410 | pubmed:affiliation | Chair and AOU Unit of Rheumatology, University of Cagliari, Italy. mathieu@medicina.unica.it | lld:pubmed |
| pubmed-article:20427410 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20427410 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2554 | entrezgene:pubmed | pubmed-article:20427410 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20427410 | lld:entrezgene |
