Linked Life Data

20427410

Source:http://linkedlifedata.com/resource/pubmed/id/20427410

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-6-28
pubmed:abstractText
Gamma-aminobutyric acid-A (GABA-A) receptors play a crucial role in regulating neuronal excitability and cognitive functions. Single-photon emission computerized tomography (SPECT) analysis of GABA-A receptors binding by (123)I-labelled Iomazenil ((123)I-IMZ) has been applied in some neuropsychiatric disorders to investigate conditions where GABA-A receptor density can be detected in several pathophysiological conditions. In this study we investigate cerebral GABA-A receptor density in a small series of patients with systemic lupus erythematosus (SLE) and cognitive impairment characterized by recurrent, episodic memory loss. Nine female patients with SLE and cognitive alterations underwent to a clinical neuropsychiatric evaluation including digital video-EEG, brain MRI, (99m)Tc-ECD brain SPECT and (123)I-IMZ brain SPECT. All patients tested showed diffuse or focal GABA-A receptor density reduction. This is, to our knowledge, the first report on GABA-A receptor density abnormalities associated with cognitive defects in SLE patients. We hypothesize that in our series a decrease in GABA-A receptor density might be related to the neurological manifestations. Further studies are needed to clarify this aspect and the possible mechanisms. GABA-A receptor density impairment might be due to the SLE-related cerebral vasculopathy, or to neuronal-reacting auto-antibodies or drugs which could interfere with GABA-A receptors expression/binding. This study may support the concept that cognitive impairment in systemic lupus erythematosus could be the outcome of fine-tuned neurotransmission alterations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1477-0962
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
918-26
pubmed:dateRevised
2011-3-11
pubmed:meshHeading
pubmed-meshheading:20427410-Adult, pubmed-meshheading:20427410-Central Nervous System, pubmed-meshheading:20427410-Cerebral Cortex, pubmed-meshheading:20427410-Cerebrovascular Circulation, pubmed-meshheading:20427410-Cognition Disorders, pubmed-meshheading:20427410-Electroencephalography, pubmed-meshheading:20427410-Female, pubmed-meshheading:20427410-Flumazenil, pubmed-meshheading:20427410-Humans, pubmed-meshheading:20427410-Iodine Radioisotopes, pubmed-meshheading:20427410-Lupus Erythematosus, Systemic, pubmed-meshheading:20427410-Magnetic Resonance Imaging, pubmed-meshheading:20427410-Middle Aged, pubmed-meshheading:20427410-Pregnancy, pubmed-meshheading:20427410-Radiopharmaceuticals, pubmed-meshheading:20427410-Receptors, GABA-A, pubmed-meshheading:20427410-Tomography, Emission-Computed, Single-Photon
pubmed:year
2010
pubmed:articleTitle
Defective cerebral gamma-aminobutyric acid-A receptor density in patients with systemic lupus erythematosus and central nervous system involvement. An observational study.
pubmed:affiliation
Chair and AOU Unit of Rheumatology, University of Cagliari, Italy. mathieu@medicina.unica.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't