Linked Life Data

20426622

Source:http://linkedlifedata.com/resource/pubmed/id/20426622

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2010-5-13
pubmed:abstractText
The polyunsaturated fatty acids in biological membranes serve as both the target and source of oxidative damage and can be regarded as the most unstable class of biomolecules in the body. Lipid peroxides arising from both spontaneous and enzymatic oxidation of polyunsaturated fatty acids are the major source of endogenous DNA damage linked to various age-related pathologies and initiating carcinogenesis. Here we describe the major types of lipid peroxide-derived DNA adducts and propose a simple dietary strategy to reduce their formation. This may be particularly beneficial to the aging organism, which has progressively impaired natural protective systems.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1557-8577
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
285-7
pubmed:meshHeading
pubmed:articleTitle
Origins of age-related DNA damage and dietary strategies for its reduction.
pubmed:affiliation
Division of Genetic and Mutagenesis II, National Institute of Health Sciences, Tokyo, Japan. gruz@nihs.go.jp
pubmed:publicationType
Journal Article, Review