Linked Life Data

20424490

Source:http://linkedlifedata.com/resource/pubmed/id/20424490

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-7-29
pubmed:abstractText
Toll-like receptors (TLRs) are a recently described arm of innate immunity. As well as responding to conserved molecular patterns found on pathogens, TLRs can also respond to endogenous ligands. Those described for TLR2 and TLR4 include molecules released following tissue injury including heat shock proteins and matrix proteins. We hypothesised that following injury, TLRs on renal tubular cells are activated by these endogenous ligands, resulting in cytokine production and cellular infiltration which propagate the fibrotic process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1660-2129
pubmed:author
pubmed:copyrightInfo
Copyright 2010 S. Karger AG, Basel.
pubmed:issnType
Electronic
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
e122-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstruction.
pubmed:affiliation
Department of Nephrology and Transplantation, King's College London, Guy's Hospital, London, UK. paramit.chowdhury@kcl.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't