Source:http://linkedlifedata.com/resource/pubmed/id/20423991
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0006826,
umls-concept:C0017337,
umls-concept:C0018270,
umls-concept:C0027627,
umls-concept:C0376358,
umls-concept:C0521324,
umls-concept:C0851285,
umls-concept:C1174836,
umls-concept:C1269955,
umls-concept:C1314939,
umls-concept:C1515655,
umls-concept:C1533157,
umls-concept:C1533691,
umls-concept:C1831731,
umls-concept:C2699153
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| pubmed:issue |
5
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| pubmed:dateCreated |
2010-5-11
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| pubmed:abstractText |
In the current study, we have examined the efficacy of a Src/Abl kinase inhibitor SKI-606 (Bosutinib) for its effect on prostate cancer growth and skeletal metastasis. Treatment of highly invasive human prostate cancer cells PC-3 and DU-145 with different doses of SKI-606 decreased Src activation, cell proliferation, migration, and invasion as determined by Matrigel Boyden chamber invasion assay. For in vivo studies, PC-3 cells were inoculated through s.c. or i.t. route into male BALB/c nu/nu or Fox Chase severe combined immunodeficient mice, respectively. Experimental animals treated with SKI-606 developed tumors of a significantly smaller volume and a significant decrease (50%) in experimental skeletal lesion area. A marked increase (32%) in bone volume to tumor volume ratio was also seen by micro-computed tomography analysis of tibias from control and experimental groups of animals. Western blot analysis showed the ability of SKI-606 to significantly decrease the phosphorylation of signaling molecules (AKT, mitogen-activated protein kinase, focal adhesion kinase) and the expression of tumor progression-associated genes uPAR, MMP-2, MMP-9, N-cadherin, fibronectin, BMP-2 (bone morphogenetic protein 2), BMP-6 (bone morphogenetic protein 6), IL-8 (interleukin 8), and TGF-beta (transforming growth factor beta) in prostate cancer cells. SKI-606 is currently in clinical trials for breast cancer and chronic myelogenous leukemia. Results from these studies provide convincing evidence for evaluating its efficacy in prostate cancer patients.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aniline Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/bosutinib
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1538-8514
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
9
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1147-57
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| pubmed:meshHeading |
pubmed-meshheading:20423991-Aniline Compounds,
pubmed-meshheading:20423991-Animals,
pubmed-meshheading:20423991-Antineoplastic Agents,
pubmed-meshheading:20423991-Bone Neoplasms,
pubmed-meshheading:20423991-Carcinoma,
pubmed-meshheading:20423991-Cell Line, Tumor,
pubmed-meshheading:20423991-Cell Proliferation,
pubmed-meshheading:20423991-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20423991-Humans,
pubmed-meshheading:20423991-Male,
pubmed-meshheading:20423991-Mice,
pubmed-meshheading:20423991-Mice, Inbred BALB C,
pubmed-meshheading:20423991-Mice, Nude,
pubmed-meshheading:20423991-Mice, SCID,
pubmed-meshheading:20423991-Neoplasm Invasiveness,
pubmed-meshheading:20423991-Neoplasm Metastasis,
pubmed-meshheading:20423991-Nitriles,
pubmed-meshheading:20423991-Prostatic Neoplasms,
pubmed-meshheading:20423991-Quinolines,
pubmed-meshheading:20423991-Tumor Burden,
pubmed-meshheading:20423991-Xenograft Model Antitumor Assays
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| pubmed:year |
2010
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| pubmed:articleTitle |
SKI-606 (Bosutinib) blocks prostate cancer invasion, growth, and metastasis in vitro and in vivo through regulation of genes involved in cancer growth and skeletal metastasis.
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| pubmed:affiliation |
Department of Medicine, McGill University Health Centre, Montreal, Quebec, Canada. shafaat.rabbani@mcgill.ca
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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