Previous studies have shown that blockade of metabotropic glutamate 5 receptors (mGluR5) results in inhibition of nicotine self-administration in experimental animals. However, these studies have not established the behavioural mechanisms which mediate these effects or the extent to which the effects of mGluR5 antagonism on nicotine self-administration reflect a selective attenuation of nicotine reinforcement.
Centre for Neuroscience, Division of Medical Sciences, Mail Point 5, University of Dundee Medical School, Ninewells Hospital, Dundee, DD1 9SY, UK. v.tronci@dundee.ac.uk
