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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-27
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pubmed:abstractText |
Recurrent pregnancy loss (RPL), defined as 3 or more consecutive miscarriages, is widely attributed either to repeated chromosomal instability in the conceptus or to uterine factors that are poorly defined. We tested the hypothesis that abnormal cyclic differentiation of endometrial stromal cells (ESCs) into specialized decidual cells predisposes to RPL, based on the observation that this process may not only be indispensable for placenta formation in pregnancy but also for embryo recognition and selection at time of implantation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-10362823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-10499541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-11106583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-12126838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-12151421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-12206468,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-15435597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-15972942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-16707507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-16709600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-16740972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-16818038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-16905025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-17053081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-17065221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-17960529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-18263639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-18511503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-18679035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-18793748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-18809929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-18997181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-19136085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-19196802,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-19255255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-19372202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-19396175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-20008415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20422017-8962658
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:AojanepongTepchongchitT,
pubmed-author:BCC,
pubmed-author:BrosensJan JJJ,
pubmed-author:HeijnenCobi JCJ,
pubmed-author:KavelaarsAnnemiekeA,
pubmed-author:KuijkEwart WEW,
pubmed-author:LandlesChristianC,
pubmed-author:LaveryStuartS,
pubmed-author:LokugamageAmali UAU,
pubmed-author:MacklonNick SNS,
pubmed-author:MardonHelen JHJ,
pubmed-author:MolokhiaMariamM,
pubmed-author:QuenbySiobhanS,
pubmed-author:ReganLesleyL,
pubmed-author:RoelenBernard A JBA,
pubmed-author:SalkerMadhuriM,
pubmed-author:TeklenburgGijsG,
pubmed-author:TrewGeoffreyG
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e10287
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pubmed:meshHeading |
pubmed-meshheading:20422017-Abortion, Habitual,
pubmed-meshheading:20422017-Adult,
pubmed-meshheading:20422017-Cell Differentiation,
pubmed-meshheading:20422017-Decidua,
pubmed-meshheading:20422017-Embryo, Mammalian,
pubmed-meshheading:20422017-Embryo Implantation,
pubmed-meshheading:20422017-Embryonic Stem Cells,
pubmed-meshheading:20422017-Endometrium,
pubmed-meshheading:20422017-Female,
pubmed-meshheading:20422017-Fertility,
pubmed-meshheading:20422017-Gastrointestinal Hormones,
pubmed-meshheading:20422017-Humans,
pubmed-meshheading:20422017-Menstrual Cycle,
pubmed-meshheading:20422017-Pregnancy,
pubmed-meshheading:20422017-Prolactin,
pubmed-meshheading:20422017-Selection, Genetic,
pubmed-meshheading:20422017-Stromal Cells,
pubmed-meshheading:20422017-Vascular Endothelial Growth Factor, Endocrine-Gland-Derived,
pubmed-meshheading:20422017-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss.
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pubmed:affiliation |
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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