Linked Life Data

20421626

Source:http://linkedlifedata.com/resource/pubmed/id/20421626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-4-27
pubmed:abstractText
This study investigated whether the single nucleotide polymorphisms (SNPs) and haplotypes of interleukin-10 (IL-10) were associated with cachexia in 223 Chinese patients with gastric cancer diagnosed by histopathological examination. Genomic DNA was extracted from peripheral blood leukocytes. The SNPs at positions -1082A/G, -819T/C, and -592A/C in the IL-10 gene promoter were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). No significant differences were found in the allele and genotype frequencies of -592A/C in patients with or without cachexia. Increased frequency of the -1082G allele was found in patients with cachexia (OR = 1.83, 95% CI, 1.00-3.33, p = 0.049). In a logistic regression analysis adjusted for body weight, carcinoma location, and stage, the -1082AG genotype was associated with an odds ratio of 1.989 (95% CI, 1.041-3.802, p = 0.037) for cachexia. The -819CC genotype was associated with an odds ratio of 3.393 (95% CI, 1.298-8.871, p = 0.013) for cachexia. Furthermore, haplotype analysis revealed that the G(1082)C(819)C(592) haplotype was associated with increased risk of cachexia as compared to the A(1082)T(819)A(592) haplotype (OR = 2.21; 95% CI, 1.14 - 4.30; p = 0.02). Our results suggest that genetic polymorphisms of IL-10 contribute to the susceptibility to cachexia in patients with gastric cancer in the Chinese population.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1550-8080
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-55
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Association of interleukin-10 gene polymorphism with cachexia in Chinese patients with gastric cancer.
pubmed:affiliation
Department of General Surgery, Qingdao University Medical College and Hospital, Shandong Province, China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't