|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2010-5-11
|
|
pubmed:abstractText |
Dendritic cells (DCs) play an important role in CD4(+) T helper (Th) cell differentiation and in the initiation of both protective and pathogenic immunity. Granulocyte/macrophage colony-stimulating factor (GM-CSF) is a DC growth factor critical for the induction of experimental autoimmune encephalomyelitis (EAE) and other autoimmune diseases, yet its mechanism of action in vivo is not fully defined. We show that GM-CSF is directly required for the accumulation of radiosensitive dermal-derived langerin(+)CD103(+) DCs in the skin and peripheral lymph nodes under steady-state and inflammatory conditions. Langerin(+)CD103(+) DCs stimulated naive myelin-reactive T cells to proliferate and produce IFN-gamma and IL-17. They were superior to other DC subsets in inducing expression of T-bet and promoting Th1 cell differentiation. Ablation of this subset in vivo conferred resistance to EAE. The current report reveals a previously unidentified role for GM-CSF in DC ontogeny and identifies langerin(+)CD103(+) DCs as an important subset in CD4(+) T cell-mediated autoimmune disease.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Cd207 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Mannose-Binding Lectins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/alpha E integrins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1540-9538
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
10
|
|
pubmed:volume |
207
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
953-61
|
|
pubmed:dateRevised |
2010-11-11
|
|
pubmed:meshHeading |
pubmed-meshheading:20421390-Animals,
pubmed-meshheading:20421390-Antigens, CD,
pubmed-meshheading:20421390-Antigens, Surface,
pubmed-meshheading:20421390-Autoimmune Diseases,
pubmed-meshheading:20421390-Cell Differentiation,
pubmed-meshheading:20421390-Dendritic Cells,
pubmed-meshheading:20421390-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:20421390-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:20421390-Immunization,
pubmed-meshheading:20421390-Integrin alpha Chains,
pubmed-meshheading:20421390-Lectins, C-Type,
pubmed-meshheading:20421390-Lymph Nodes,
pubmed-meshheading:20421390-Mannose-Binding Lectins,
pubmed-meshheading:20421390-Mice,
pubmed-meshheading:20421390-Receptors, Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:20421390-Skin,
pubmed-meshheading:20421390-Th1 Cells,
pubmed-meshheading:20421390-Th2 Cells
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization.
|
|
pubmed:affiliation |
Interdepartmental Graduate Program in Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
