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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-8-13
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pubmed:abstractText |
Tumours secrete proangiogenic factors to induce the ingrowth of blood vessels, the end targets of which are vascular endothelial cells (ECs). The MEOX2 homeoprotein inhibits nuclear factor-kappaB (NF-kappaB) signalling and EC activation in response to serum and proangiogenic factors. We hypothesize that MEOX2 interacts with components of this pathway in vascular ECs to modulate NF-kappaB activity and EC activation and that these interactions depend upon specific domains within the MEOX2 protein.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-10026139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-10359349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-10591139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-10713675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-11238099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-11683410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-11912159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-11983155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-12138201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-12842453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-12972430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-15499023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-15735029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-15737846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-16116430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-16267257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-16623771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-17074759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-17192276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-17464324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-17957028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-18283548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-7607679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-7784172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-8098844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-8754823,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-9224717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20421348-9850083
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ID1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ID3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/IKBKB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Inhibitor of Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/MEOX2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Meox2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RELA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
723-31
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pubmed:dateRevised |
2011-9-13
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pubmed:meshHeading |
pubmed-meshheading:20421348-Animals,
pubmed-meshheading:20421348-Binding Sites,
pubmed-meshheading:20421348-Cell Nucleus,
pubmed-meshheading:20421348-Cells, Cultured,
pubmed-meshheading:20421348-Endothelial Cells,
pubmed-meshheading:20421348-Gene Expression Regulation,
pubmed-meshheading:20421348-Genes, Reporter,
pubmed-meshheading:20421348-Homeodomain Proteins,
pubmed-meshheading:20421348-Humans,
pubmed-meshheading:20421348-I-kappa B Kinase,
pubmed-meshheading:20421348-Immunoprecipitation,
pubmed-meshheading:20421348-Inhibitor of Differentiation Protein 1,
pubmed-meshheading:20421348-Inhibitor of Differentiation Proteins,
pubmed-meshheading:20421348-Intercellular Adhesion Molecule-1,
pubmed-meshheading:20421348-Interleukin-6,
pubmed-meshheading:20421348-Microscopy, Fluorescence,
pubmed-meshheading:20421348-Muscle Proteins,
pubmed-meshheading:20421348-Neoplasm Proteins,
pubmed-meshheading:20421348-Promoter Regions, Genetic,
pubmed-meshheading:20421348-Protein Interaction Domains and Motifs,
pubmed-meshheading:20421348-Protein Interaction Mapping,
pubmed-meshheading:20421348-Protein Structure, Tertiary,
pubmed-meshheading:20421348-Rats,
pubmed-meshheading:20421348-Transcription Factor RelA,
pubmed-meshheading:20421348-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
MEOX2 regulates nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta.
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