| pubmed-article:20420385 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0001527 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0600500 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0184511 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0178499 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:20420385 | lifeskim:mentions | umls-concept:C0522529 | lld:lifeskim |
| pubmed-article:20420385 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20420385 | pubmed:dateCreated | 2010-5-20 | lld:pubmed |
| pubmed-article:20420385 | pubmed:abstractText | A peptide nucleic acid (PNA) targeting a splice junction of the murine PTEN primary transcript was covalently conjugated to various basic peptides. When systemically administered to healthy mice, the conjugates displayed sequence-specific alteration of PTEN mRNA splicing as well as inhibition of full length PTEN protein expression. Correlating activity with drug concentration in various tissues indicated strong tissue-dependence, with highest levels of activity observed in adipose tissue. While the presence of a peptide carrier was found to be crucial for efficient delivery to tissue, little difference was observed between the various peptides evaluated. A second PNA-conjugate targeting the murine insulin receptor primary transcript showed a similar activity profile, suggesting that short basic peptides can generally be used to effectively deliver peptide nucleic acids to adipose tissue. | lld:pubmed |
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| pubmed-article:20420385 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20420385 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20420385 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20420385 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20420385 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20420385 | pubmed:month | May | lld:pubmed |
| pubmed-article:20420385 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:MoniaBrett... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:MaierMartin... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:BennettC... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:CoreyDavid... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:HuJiaxinJ | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:GriffeyRichar... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:NulfChristoph... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:SwayzeEric... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:WancewiczEdwa... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:VickersTimoth... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:KinbergerGart... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:GausHansH | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:SiwkowskiAndr... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:AlbertshoferK... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:BerdejaAndres... | lld:pubmed |
| pubmed-article:20420385 | pubmed:author | pubmed-author:WingerTheodor... | lld:pubmed |
| pubmed-article:20420385 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20420385 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:20420385 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:20420385 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20420385 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20420385 | pubmed:pagination | 3919-26 | lld:pubmed |
| pubmed-article:20420385 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:20420385 | pubmed:meshHeading | pubmed-meshheading:20420385... | lld:pubmed |
| pubmed-article:20420385 | pubmed:meshHeading | pubmed-meshheading:20420385... | lld:pubmed |
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| pubmed-article:20420385 | pubmed:meshHeading | pubmed-meshheading:20420385... | lld:pubmed |
| pubmed-article:20420385 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20420385 | pubmed:articleTitle | Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue. | lld:pubmed |
| pubmed-article:20420385 | pubmed:affiliation | Isis Pharmaceuticals, Inc., Carlsbad, California 92008, USA. | lld:pubmed |
| pubmed-article:20420385 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20420385 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
