Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-5-7
pubmed:abstractText
Fibrogenesis is a pathological wound repair process that fails to cease, even when the initial insult has been removed. Fibroblasts are principal mediators of fibrosis, and fibroblasts from fibrotic tissues fail to return to their quiescent stage, including when cultured in vitro. In a search for underlying molecular mechanisms, we hypothesized that this perpetuation of fibrogenesis is caused by epigenetic modifications. We demonstrate here that hypermethylation of RASAL1, encoding an inhibitor of the Ras oncoprotein, is associated with the perpetuation of fibroblast activation and fibrogenesis in the kidney. RASAL1 hypermethylation is mediated by the methyltransferase Dnmt1 in renal fibrogenesis, and kidney fibrosis is ameliorated in Dnmt1(+/-) heterozygous mice. These studies demonstrate that epigenetic modifications may provide a molecular basis for perpetuated fibroblast activation and fibrogenesis in the kidney.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-10555141, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-10589672, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-11168939, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-11281740, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-12239251, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-12509763, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-12759573, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-12808448, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-14627790, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-1497573, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-15021234, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-15057271, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-15372103, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-15632414, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-15793581, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-15960973, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-16051167, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-1606615, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-16149092, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-16284088, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-16572188, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-16906157, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17035610, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17214585, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17320506, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17406479, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17525249, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17640920, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-17960246, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-2042649, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-2042650, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-20448575, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-2062038, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-20734473, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-2547513, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-3304147, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-3659719, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-7489351, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-7910173, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-8247133, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-8989727, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-9104823, http://linkedlifedata.com/resource/pubmed/commentcorrection/20418885-9893128
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1546-170X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
544-50
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Methylation determines fibroblast activation and fibrogenesis in the kidney.
pubmed:affiliation
Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
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