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pubmed:abstractText |
Critical limb ischemia (CLI) is a severe peripheral arterial disease, characterized by rest pain, ulcers and gangrene in the legs. Gas6 is a vitamin K-dependent protein, which binds and activates the tyrosine kinase receptor Axl. Gas6-mediated Axl-signaling influences endothelial activation, neointima formation and immune regulation. Axl can be cleaved and soluble Axl (sAxl) is detectable in circulation.
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pubmed:affiliation |
Lund University, Department of Laboratory Medicine, Clinical Chemistry, Wallenberg Laboratory, Entrance 46, Floor 6, University Hospital, SE-20502 Malmö, Sweden. Carl.ekman@med.lu.se
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