Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1991-7-11
pubmed:abstractText
The fragile X syndrome (FraX), the most common inherited form of mental retardation, has been located to Xq27.3. As a step in the molecular analysis of this mutation, we have cloned a contiguous 1.8 Mb region containing the entire fragile X region in YAC and cosmid clones. The cloned area defines a region of 50 kb containing a CpG island, found to be selectively methylated in patients expressing the fragile X phenotype. In this 50kb area we have localised the breakpoints of four somatic cell hybrids selected to break at the position of the fragile site. Fluorescence in-situ hybridisation of cosmids flanking this area shows that the breakpoints, the CpG island and the fragile site coincide.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-1672039, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-1969225, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-1974408, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-1997211, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2006411, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2154694, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2161516, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2309697, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2339126, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2573953, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2880670, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-2906041, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-3545058, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-3603029, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-36752, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-3692144, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-3838733, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-4080545, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-6300789, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-6324578, http://linkedlifedata.com/resource/pubmed/commentcorrection/2041732-6712153
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0305-1048
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
2567-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Molecular cloning and analysis of the fragile X region in man.
pubmed:affiliation
Deutsches Krebsforschungszentrum, Institut fuer Virusforschung, Heidelberg, FRG.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't