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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-5-4
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pubmed:abstractText |
Starting with a high-throughput screening lead, a novel series of CCR5 antagonists was developed utilizing an information-based approach. Improvement of pharmacokinetic properties for the series was pursued by SAR exploration of the lead template. The synthesis, SAR and biological profiles of the series are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BerryPamelaP,
pubmed-author:ChenLijingL,
pubmed-author:CournoyerDickD,
pubmed-author:DerosierAndreA,
pubmed-author:DioszegiMariannaM,
pubmed-author:FilonovaLubovL,
pubmed-author:GleasonShelleyS,
pubmed-author:HeilekGabrielleG,
pubmed-author:JekleAndreasA,
pubmed-author:JiChanghuaC,
pubmed-author:LeeEun KEK,
pubmed-author:LemoineRemyR,
pubmed-author:LinXiao-FaXF,
pubmed-author:LoughheadDavid GDG,
pubmed-author:MankaJasonJ,
pubmed-author:MauCheng-ICI,
pubmed-author:MelvilleChris RCR,
pubmed-author:PadillaFernandoF,
pubmed-author:PetersenAnn CAC,
pubmed-author:RotsteinDavid MDM,
pubmed-author:SankuratriSuryaS,
pubmed-author:SettiLina QLQ,
pubmed-author:WannerJuttaJ,
pubmed-author:WellerPaulP
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pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3116-9
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pubmed:meshHeading |
pubmed-meshheading:20417098-Animals,
pubmed-meshheading:20417098-Anti-HIV Agents,
pubmed-meshheading:20417098-Benzamides,
pubmed-meshheading:20417098-HIV Fusion Inhibitors,
pubmed-meshheading:20417098-Humans,
pubmed-meshheading:20417098-Microsomes, Liver,
pubmed-meshheading:20417098-Pyrroles,
pubmed-meshheading:20417098-Rats,
pubmed-meshheading:20417098-Receptors, CCR5,
pubmed-meshheading:20417098-Structure-Activity Relationship
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pubmed:year |
2010
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pubmed:articleTitle |
Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists.
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pubmed:affiliation |
Roche Palo Alto LLC, Palo Alto, CA 94304, USA. david.rotstein@comcast.net
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pubmed:publicationType |
Journal Article
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