Source:http://linkedlifedata.com/resource/pubmed/id/20413888
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-7-5
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| pubmed:abstractText |
In this study we investigated the association between plasma levels of eight forms of vitamin E and incidence of Alzheimer's disease (AD) among oldest-old individuals in a population-based setting. A dementia-free sample of 232 subjects aged 80+ years, derived from the Kungsholmen Project, was followed-up to 6 years to detect incident AD. Plasma levels of vitamin E (alpha-, beta-, gamma, and delta-tocopherol; alpha-, beta-, gamma-, and delta-tocotrienol) were measured at baseline. Vitamin E forms-AD association was analyzed with Cox proportional hazard model after adjustment for several potential confounders. Subjects with plasma levels of total tocopherols, total tocotrienols, or total vitamin E in the highest tertile had a reduced risk of developing AD in comparison to persons in the lowest tertile. Multi-adjusted hazard ratios (HRs) and 95% confidence interval (CI) were 0.55 (0.32-0.94) for total tocopherols, 0.46 (0.23-0.92) for total tocotrienols, and 0.55 (0.32-0.94) for total vitamin E. When considering each vitamin E form, the risk of developing AD was reduced only in association with high plasma levels of beta-tocopherol (HR: 0.62, 95% CI 0.39-0.99), whereas alpha-tocopherol, alpha- tocotrienol, and beta-tocotrienol showed only a marginally significant effect in the multiadjusted model [HR (95% CI): alpha-tocopherol: 0.72 (0.48-1.09); alpha-tocotrienol: 0.70 (0.44-1.11); beta-tocotrienol: 0.69 (0.45-1.06)]. In conclusion, high plasma levels of vitamin E are associated with a reduced risk of AD in advanced age. The neuroprotective effect of vitamin E seems to be related to the combination of different forms, rather than to alpha-tocopherol alone, whose efficacy in interventions against AD is currently debated.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1875-8908
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1029-37
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| pubmed:meshHeading |
pubmed-meshheading:20413888-Aged,
pubmed-meshheading:20413888-Aged, 80 and over,
pubmed-meshheading:20413888-Aging,
pubmed-meshheading:20413888-Alzheimer Disease,
pubmed-meshheading:20413888-Cholesterol,
pubmed-meshheading:20413888-Data Collection,
pubmed-meshheading:20413888-Dementia,
pubmed-meshheading:20413888-Female,
pubmed-meshheading:20413888-Humans,
pubmed-meshheading:20413888-Male,
pubmed-meshheading:20413888-Neuropsychological Tests,
pubmed-meshheading:20413888-Nutritional Status,
pubmed-meshheading:20413888-Population,
pubmed-meshheading:20413888-Proportional Hazards Models,
pubmed-meshheading:20413888-Risk Reduction Behavior,
pubmed-meshheading:20413888-Socioeconomic Factors,
pubmed-meshheading:20413888-Sweden,
pubmed-meshheading:20413888-Vitamin E
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| pubmed:year |
2010
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| pubmed:articleTitle |
High plasma levels of vitamin E forms and reduced Alzheimer's disease risk in advanced age.
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| pubmed:affiliation |
Aging Research Center, Karolinska Institutet, Stockholm, Sweden. francesca.mangialasche@ki.se
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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