Source:http://linkedlifedata.com/resource/pubmed/id/20413851
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-7-5
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| pubmed:abstractText |
Amyloid-beta (Abeta) accumulates in several types of retinal degeneration and in Alzheimer's disease (AD), but its source has been unclear. We detected the neuronal 695 amino acid form of amyloid-beta protein precursor (AbetaPP) in the normal retina and AbetaPP751 in the retinal pigment epithelium (RPE) and anterior eye tissues. Similar to the brain, alpha- and beta-secretases cleaved AbetaPP to soluble derivatives (sAbetaPP) alpha or beta and membrane-bound C-terminal fragments alpha or beta in the retina and RPE. Levels of sAbetaPP were particularly high in the vitreous and low in aqueous humor revealing a molecular barrier for AbetaPP. In contrast, Abeta40 and Abeta42 levels were only 50% lower in the aqueous than the vitreous humor, indicating relatively barrier-free movement of Abeta. These studies demonstrated a relatively high yield of AbetaPP and Abeta in the ocular fluids, which may serve as a trackable marker for AD. In addition, failure of free clearance from the eye may trigger retina degeneration in a manner similar to Abeta-related neurodegeneration in AD.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid Precursor Protein Secretases,
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1875-8908
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1243-53
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| pubmed:dateRevised |
2011-5-12
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| pubmed:meshHeading |
pubmed-meshheading:20413851-Amino Acid Sequence,
pubmed-meshheading:20413851-Amyloid Precursor Protein Secretases,
pubmed-meshheading:20413851-Amyloid beta-Protein Precursor,
pubmed-meshheading:20413851-Animals,
pubmed-meshheading:20413851-Aqueous Humor,
pubmed-meshheading:20413851-Body Fluids,
pubmed-meshheading:20413851-Brain Chemistry,
pubmed-meshheading:20413851-Cattle,
pubmed-meshheading:20413851-Central Nervous System,
pubmed-meshheading:20413851-Cycloheximide,
pubmed-meshheading:20413851-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:20413851-Eye,
pubmed-meshheading:20413851-Mice,
pubmed-meshheading:20413851-Mice, Inbred BALB C,
pubmed-meshheading:20413851-Molecular Sequence Data,
pubmed-meshheading:20413851-Protein Synthesis Inhibitors,
pubmed-meshheading:20413851-Retina,
pubmed-meshheading:20413851-Retinal Pigment Epithelium,
pubmed-meshheading:20413851-Vitreous Body
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| pubmed:year |
2010
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| pubmed:articleTitle |
Differential accumulation of secreted AbetaPP metabolites in ocular fluids.
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| pubmed:affiliation |
Department of Neurosciences, Medical University of South Carolina, Charleston, SC, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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