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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2010-6-11
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pubmed:abstractText |
Angiogenesis contributes to physiological and pathological conditions, including atherosclerosis. The Rap1 small G protein regulates vascular integrity and angiogenesis. However, little is known about the effectors of Rap1 involved in angiogenesis. It is not known whether afadin, an adherens junction protein that connects immunoglobulin-like adhesion molecule nectins to the actin cytoskeleton and binds activated Rap1, plays a role in angiogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RAC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/afadin,
http://linkedlifedata.com/resource/pubmed/chemical/rac1 GTP-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/rap1 GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4571
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pubmed:author |
pubmed-author:AmanoHisayukiH,
pubmed-author:HirataKen-ichiK,
pubmed-author:KinugasaMitsuoM,
pubmed-author:MajimaTakashiT,
pubmed-author:MiyataMuneakiM,
pubmed-author:MiyoshiJunJ,
pubmed-author:NagamatsuYuichiY,
pubmed-author:OgitaHisakazuH,
pubmed-author:RikitakeYoshiyukiY,
pubmed-author:Satomi-KobayashiSeimiS,
pubmed-author:TakahashiMotonoriM,
pubmed-author:TakaiYoshimiY,
pubmed-author:TawaHidetoH
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1731-42
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:20413783-Animals,
pubmed-meshheading:20413783-Apoptosis,
pubmed-meshheading:20413783-Cell Movement,
pubmed-meshheading:20413783-Cell Proliferation,
pubmed-meshheading:20413783-Cells, Cultured,
pubmed-meshheading:20413783-Disease Models, Animal,
pubmed-meshheading:20413783-Endothelial Cells,
pubmed-meshheading:20413783-Hindlimb,
pubmed-meshheading:20413783-Humans,
pubmed-meshheading:20413783-Intercellular Junctions,
pubmed-meshheading:20413783-Ischemia,
pubmed-meshheading:20413783-Lysophospholipids,
pubmed-meshheading:20413783-Male,
pubmed-meshheading:20413783-Mice,
pubmed-meshheading:20413783-Mice, Inbred C57BL,
pubmed-meshheading:20413783-Mice, Knockout,
pubmed-meshheading:20413783-Microfilament Proteins,
pubmed-meshheading:20413783-Muscle, Skeletal,
pubmed-meshheading:20413783-Neovascularization, Physiologic,
pubmed-meshheading:20413783-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:20413783-Protein Transport,
pubmed-meshheading:20413783-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:20413783-RNA Interference,
pubmed-meshheading:20413783-Rats,
pubmed-meshheading:20413783-Recombinant Fusion Proteins,
pubmed-meshheading:20413783-Retinal Neovascularization,
pubmed-meshheading:20413783-Signal Transduction,
pubmed-meshheading:20413783-Sphingosine,
pubmed-meshheading:20413783-Time Factors,
pubmed-meshheading:20413783-Vascular Endothelial Growth Factor A,
pubmed-meshheading:20413783-rac1 GTP-Binding Protein,
pubmed-meshheading:20413783-rap1 GTP-Binding Proteins
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pubmed:year |
2010
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pubmed:articleTitle |
Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis.
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pubmed:affiliation |
Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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