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rdf:type |
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lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0025149,
umls-concept:C0035647,
umls-concept:C0035820,
umls-concept:C0205314,
umls-concept:C0431085,
umls-concept:C0597032,
umls-concept:C0679622,
umls-concept:C1333894,
umls-concept:C1422386,
umls-concept:C1514983,
umls-concept:C2745888
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|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2010-6-16
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|
pubmed:abstractText |
Medulloblastomas are the most common malignant brain tumors in childhood. Survivors suffer from high morbidity because of therapy-related side effects. Thus, therapies targeting tumors in a specific manner with small molecules such as histone deacetylase (HDAC) inhibitors are urgently warranted. This study investigated the expression levels of individual human HDAC family members in primary medulloblastoma samples, their potential as risk stratification markers, and their roles in tumor cell growth.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:DeubzerHedwig EHE,
pubmed-author:Kopp-SchneiderAnnetteA,
pubmed-author:KorshunovAndreyA,
pubmed-author:LodriniMarcoM,
pubmed-author:MildeTillT,
pubmed-author:NorthcottPaulP,
pubmed-author:OehmeInaI,
pubmed-author:PfisterStefanS,
pubmed-author:RemkeMarcM,
pubmed-author:TaylorMichael DMD,
pubmed-author:WittOlafO,
pubmed-author:von DeimlingAndreasA
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pubmed:copyrightInfo |
(c) 2010 AACR.
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pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
16
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
3240-52
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|
pubmed:meshHeading |
pubmed-meshheading:20413433-Brain Neoplasms,
pubmed-meshheading:20413433-Cell Proliferation,
pubmed-meshheading:20413433-Gene Knockdown Techniques,
pubmed-meshheading:20413433-Histone Deacetylases,
pubmed-meshheading:20413433-Humans,
pubmed-meshheading:20413433-Medulloblastoma,
pubmed-meshheading:20413433-Prognosis,
pubmed-meshheading:20413433-Repressor Proteins,
pubmed-meshheading:20413433-Risk,
pubmed-meshheading:20413433-Tumor Cells, Cultured,
pubmed-meshheading:20413433-Tumor Markers, Biological,
pubmed-meshheading:20413433-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth.
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|
pubmed:affiliation |
Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center, Heidelberg, Germany. t.milde@dkfz.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
