Linked Life Data

20413364

Source:http://linkedlifedata.com/resource/pubmed/id/20413364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-6-14
pubmed:abstractText
Whether combination lipoprotein therapy targeting apolipoprotein B (apoB)- and apoA-containing lipoprotein particles and triglycerides (TGs) in low-risk, asymptomatic subjects with coronary atherosclerosis alters the natural progression of plaques is unknown. This study was designed to compare the progression of coronary atherosclerosis in asymptomatic, low-risk subjects without previously known coronary artery disease but with the presence of plaque on a combination of atorvastatin 40 mg plus fenofibric acid 135 mg daily for 18 months, using cardiovascular computed tomography (CCT). This is an investigator-initiated, single-center, prospective, double-blind, randomized, placebo-controlled, parallel-arm study. Asymptomatic subjects at low risk of cardiovascular events defined as <10% 10-year risk based on the Framingham Risk Score will be recruited, if they do not qualify for lipoprotein-lowering therapy based on the National Cholesterol Education Panel Adult Treatment Panel III guidelines. Subjects will qualify based on lipid parameters if their low-density lipoprotein cholesterol is >/=100 mg/dL and <190 mg/dL, TGs are >150 mg/dL, and the TGs/high-density lipoprotein cholesterol ratio is >3.5. Patients must have nonobstructive plaque based on CCT. Randomization will be 1:1 to either a combination of atorvastatin 40 mg plus fenofibric acid 135 mg daily or placebo for 18 months. Patients will undergo CCT at baseline and at the end of the treatment period. The primary end point will be the between-group difference in percent atheroma volume. Ultimately, this study can guide physicians about the use of a statin-fibric acid derivative combination in asymptomatic, low-risk persons with atherosclerosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1876-861X
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
164-72
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:20413364-Biological Markers, pubmed-meshheading:20413364-Coronary Angiography, pubmed-meshheading:20413364-Coronary Artery Disease, pubmed-meshheading:20413364-Double-Blind Method, pubmed-meshheading:20413364-Drug Therapy, Combination, pubmed-meshheading:20413364-Fenofibrate, pubmed-meshheading:20413364-Georgia, pubmed-meshheading:20413364-Heptanoic Acids, pubmed-meshheading:20413364-Humans, pubmed-meshheading:20413364-Hydroxymethylglutaryl-CoA Reductase Inhibitors, pubmed-meshheading:20413364-Hypolipidemic Agents, pubmed-meshheading:20413364-Lipids, pubmed-meshheading:20413364-Prospective Studies, pubmed-meshheading:20413364-Pyrroles, pubmed-meshheading:20413364-Research Design, pubmed-meshheading:20413364-Tomography, X-Ray Computed, pubmed-meshheading:20413364-Treatment Outcome
pubmed:articleTitle
Cardiovascular computed tomographic assessment of the effect of combination lipoprotein therapy on coronary arterial plaque: rationale and design of the AFRICA (Atorvastatin plus Fenofibric acid in the Reduction of Intermediate Coronary Atherosclerosis) study.
pubmed:affiliation
Piedmont Heart Institute, 1968 Peachtree Road, NW, Atlanta, GA 30309, USA. szilard.voros@piedmont.org
pubmed:publicationType
Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't