Source:http://linkedlifedata.com/resource/pubmed/id/20412468
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-4-23
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| pubmed:abstractText |
N-terminal prohormone B-type natriuretic peptide (NT-proBNP) is an important biomarker of prognosis in heart failure and single valve disease. There are limited studies of complex valve disease. Patients with complex valve disease adopt a sedentary lifestyle, so symptoms may be difficult to detect. The authors aimed to determine whether NT-proBNP correlates with the severity of the valve lesion and underlying cardiac function and whether resting NT-proBNP predicts impaired peak VO(2) in patients with complex valve disease. Forty-five patients with complex moderate to severe stenosis or regurgitation of the heart valves underwent a clinical assessment, echocardiography, resting NT-proBNP assessment, and formal cardiopulmonary exercise testing. In a multivariate analysis, the log NT-proBNP (beta=-9.3, SE=1.9, P<.0001) and lean body weight (beta=0.59, SE=0.22, P=.01) were dominant independent predictors of peak VO(2). An NT-proBNP value of 84 pmol/L had 77% sensitivity and 70% specificity to predict impaired functional capacity, peak VO(2) <60% (predicted), area under the curve=0.80. Resting NT-proBNP was the best predictor of peak VO(2) in patients with complex valve disease, while symptoms and ejection fraction are a less reliable guide.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Natriuretic Peptide, Brain,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/pro-brain natriuretic peptide (1-76)
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1751-7133
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
16
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
50-4
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| pubmed:dateRevised |
2011-10-19
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| pubmed:meshHeading |
pubmed-meshheading:20412468-Biological Markers,
pubmed-meshheading:20412468-Exercise Test,
pubmed-meshheading:20412468-Female,
pubmed-meshheading:20412468-Heart Failure,
pubmed-meshheading:20412468-Heart Valve Diseases,
pubmed-meshheading:20412468-Humans,
pubmed-meshheading:20412468-Linear Models,
pubmed-meshheading:20412468-Male,
pubmed-meshheading:20412468-Middle Aged,
pubmed-meshheading:20412468-Multivariate Analysis,
pubmed-meshheading:20412468-Natriuretic Peptide, Brain,
pubmed-meshheading:20412468-Oxygen Consumption,
pubmed-meshheading:20412468-Peptide Fragments,
pubmed-meshheading:20412468-Prognosis,
pubmed-meshheading:20412468-Prospective Studies,
pubmed-meshheading:20412468-ROC Curve,
pubmed-meshheading:20412468-Sensitivity and Specificity,
pubmed-meshheading:20412468-Severity of Illness Index,
pubmed-meshheading:20412468-Statistics as Topic
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| pubmed:articleTitle |
The role of natriuretic peptides in patients with chronic complex (mixed or multiple) heart valve disease.
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| pubmed:affiliation |
Department of Cardiology, Griffiths University Medical School, Gold Coast Hospital, Gold Coast, Queensland, Australia. naylinbissessor@hotmail.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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