Linked Life Data

20411765

Source:http://linkedlifedata.com/resource/pubmed/id/20411765

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
73
pubmed:dateCreated
2010-4-23
pubmed:abstractText
The degeneration of nigral dopaminergic (DA-) neurons is the histopathologic hallmark of Parkinson's disease (PD), but not all nigral DA-cells show the same susceptibility to degeneration. This starts in DA-cells in the ventrolateral and caudal regions of the susbtantia nigra (SN) and progresses to DA-cells in the dorsomedial and rostral regions of the SN and the ventral tegmental area, where many neurons remain intact until the final stages of the disease. This fact indicates a relationship between the topographic distribution of midbrain DA-cells and their differential vulnerability, and the possibility that this differential vulnerability is associated with phenotypic differences between different subpopulations of nigral DA-cells. Studies carried out during the last two decades have contributed to establishing the existence of different compartments of nigral DA-cells according to their neurochemical profile, and a possible relationship between the expression of some factors and the relative vulnerability or resistance of DA-cell subpopulations to degeneration. These aspects are reviewed and discussed here.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0303-6995
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
21-37
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Phenotype, compartmental organization and differential vulnerability of nigral dopaminergic neurons.
pubmed:affiliation
Department of Anatomy, Faculty of Medicine, University of La Laguna, 38071, La Laguna, Tenerife, Spain. tgonhern@ull.es
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't