| pubmed-article:20411395 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0282547 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0001347 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:20411395 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:20411395 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20411395 | pubmed:dateCreated | 2010-6-9 | lld:pubmed |
| pubmed-article:20411395 | pubmed:abstractText | Three different primary rat hepatocyte culture methods were compared for their ability to allow the secretion of fibrinogen and albumin under basal and IL-6-stimulated conditions. These culture methods comprised the co-culture of hepatocytes with rat liver epithelial cells (CC-RLEC), a collagen type I sandwich culture (SW) and a conventional primary hepatocyte monolayer culture (ML). Basal albumin secretion was most stable over time in SW. Fibrinogen secretion was induced by IL-6 in all cell culture models. Compared with ML, CC-RLEC showed an almost three-fold higher fibrinogen secretion under both control and IL-6-stimulated conditions. Induction of fibrinogen release by IL-6 was lowest in SW. Albumin secretion was decreased after IL-6 stimulation in both ML and CC-RLEC. Thus, cells growing under the various primary hepatocyte cell culture techniques react differently to IL-6 stimulation with regard to acute-phase protein secretion. CC-RLEC is the preferred method for studying cytokine-mediated induction of acute-phase proteins, because of the pronounced stimulation of fibrinogen secretion upon IL-6 exposure under these conditions. | lld:pubmed |
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| pubmed-article:20411395 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20411395 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20411395 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20411395 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20411395 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20411395 | pubmed:issn | 1432-0878 | lld:pubmed |
| pubmed-article:20411395 | pubmed:author | pubmed-author:RogiersVeraV | lld:pubmed |
| pubmed-article:20411395 | pubmed:author | pubmed-author:HaagsmanHenk... | lld:pubmed |
| pubmed-article:20411395 | pubmed:author | pubmed-author:PapeleuPeggyP | lld:pubmed |
| pubmed-article:20411395 | pubmed:author | pubmed-author:VanhaeckeTama... | lld:pubmed |
| pubmed-article:20411395 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:20411395 | pubmed:author | pubmed-author:PetersStephan... | lld:pubmed |
| pubmed-article:20411395 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20411395 | pubmed:volume | 340 | lld:pubmed |
| pubmed-article:20411395 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20411395 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20411395 | pubmed:pagination | 451-7 | lld:pubmed |
| pubmed-article:20411395 | pubmed:dateRevised | 2010-9-30 | lld:pubmed |
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| pubmed-article:20411395 | pubmed:meshHeading | pubmed-meshheading:20411395... | lld:pubmed |
| pubmed-article:20411395 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20411395 | pubmed:articleTitle | Co-culture of primary rat hepatocytes with rat liver epithelial cells enhances interleukin-6-induced acute-phase protein response. | lld:pubmed |
