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pubmed:abstractText |
Inherent property of the motoneurons of the peripheral nervous system is their ability to recover, at least in part, upon injury. To this end different factors are expressed and are thought to play important role in the regeneration processes. These factors are diverse, and range from transcription factors and chemokines, to molecules of the extracellular matrix. Transforming growth factor beta (TGF-beta) is a protein with diverse actions controlling cell growth and proliferation. In the extracellular matrix it is found bound to decorin a proteoglycan involved in cell adhesion and cell signaling. In the present study we investigate the expression of TGF-beta and decorin at different time points, in the regenerating sciatic nerve of a seven day old rat, having suffered nerve crush injury, over a period of one month.
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pubmed:affiliation |
Laboratory of Physiology, Department of Physiology and Pharmacology, Medical School, Aristotle University of Thessaloniki, and 2nd Department of Neurology, AHEPA University Hospital, Thessaloniki, Greece. kritis@med.auth.gr
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