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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2010-7-15
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pubmed:abstractText |
Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, through dopaminergic mesolimbic circuitry. Carriers of the 66Met+/A1+ variant scored lowest on Novelty Seeking and highest on Harm Avoidance, compared to all other genotype groups. These participants are characterized by a relatively low D(2) receptor density in the striatum and an impaired activity-dependent secretion of BDNF. This is one of the first genetic association studies to show a modulatory role for BDNF genetic variation on genetically mediated differences in the mesolimbic dopaminergic system in the context of human personality.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20410875-10395223,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1740-634X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
35
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1860-7
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:20410875-Adolescent,
pubmed-meshheading:20410875-Adult,
pubmed-meshheading:20410875-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:20410875-Epistasis, Genetic,
pubmed-meshheading:20410875-Exploratory Behavior,
pubmed-meshheading:20410875-Female,
pubmed-meshheading:20410875-Gene Frequency,
pubmed-meshheading:20410875-Genetic Association Studies,
pubmed-meshheading:20410875-Genotype,
pubmed-meshheading:20410875-Harm Reduction,
pubmed-meshheading:20410875-Humans,
pubmed-meshheading:20410875-Male,
pubmed-meshheading:20410875-Methionine,
pubmed-meshheading:20410875-Multivariate Analysis,
pubmed-meshheading:20410875-Polymorphism, Genetic,
pubmed-meshheading:20410875-Principal Component Analysis,
pubmed-meshheading:20410875-Protein-Serine-Threonine Kinases,
pubmed-meshheading:20410875-Questionnaires,
pubmed-meshheading:20410875-Receptors, Dopamine D2,
pubmed-meshheading:20410875-Self Concept,
pubmed-meshheading:20410875-Valine,
pubmed-meshheading:20410875-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts novelty seeking and harm avoidance.
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pubmed:affiliation |
Department of Psychology, Laboratory of Neurogenetics, University of Bonn, Bonn, Germany. christian.montag@uni-bonn-diff.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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