Source:http://linkedlifedata.com/resource/pubmed/id/20410811
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2010-4-27
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| pubmed:abstractText |
Only a few cases of gastric adenocarcinoma of fundic gland type have been reported. Gastric adenocarcinoma with chief cell differentiation (GA-CCD) has been recently reported as a new variant of gastric adenocarcinoma. However, its clinicopathologic features are uncertain. To elucidate them, GA-CCDs exhibiting pepsinogen-I expression (10 lesions: Group A) and randomly selected gastric adenocarcinomas of differentiated type (111 lesions: Group B) were evaluated in this study. Cell differentiation by MUC2, MUC5AC, MUC6, CD10, pepsinogen-I, H+/K+-ATPase and chromogranin A, cell proliferation by Ki-67, and overexpression of p53 protein were evaluated immunohistochemically. In Group A, all GA-CCDs were located in the upper third of the stomach. Tumors were small, with the average maximum diameter ranging from 4 to 20 (average, 8.6) mm. Histologically, GA-CCDs were well-differentiated adenocarcinomas composed of pale gray-blue, basophilic columnar cells with mild nuclear atypia, resembling chief cells. Immunohistochemically, scattered positivity for H+/K+-ATPase was observed in addition to expression of pepsinogen-I and MUC6, indicating focal differentiation toward parietal cells. In Group B, pepsinogen-I was very focally expressed in 2 cases. As these 2 cases exhibited different clinicopathological and histologic features, they cannot be categorized as GA-CCD. Mild atypism, no lymphovascular invasion, low proliferative activity, no overexpression of p53, and no recurrence indicated less aggressiveness of GA-CCD. GA-CCD is rare, but it has distinct clinicopathological characteristics, especially in terms of tumor location, histologic features, phenotypic expression, and low-grade malignancy. We propose gastric adenocarcinoma of fundic gland type (chief cell predominant type) as a new entity of gastric adenocarcinoma.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1532-0979
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
34
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
609-19
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| pubmed:meshHeading |
pubmed-meshheading:20410811-Adenocarcinoma,
pubmed-meshheading:20410811-Adult,
pubmed-meshheading:20410811-Aged,
pubmed-meshheading:20410811-Chief Cells, Gastric,
pubmed-meshheading:20410811-Female,
pubmed-meshheading:20410811-Gastric Fundus,
pubmed-meshheading:20410811-H(+)-K(+)-Exchanging ATPase,
pubmed-meshheading:20410811-Humans,
pubmed-meshheading:20410811-Male,
pubmed-meshheading:20410811-Middle Aged,
pubmed-meshheading:20410811-Pepsinogen A,
pubmed-meshheading:20410811-Stomach Neoplasms,
pubmed-meshheading:20410811-Tumor Markers, Biological
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| pubmed:year |
2010
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| pubmed:articleTitle |
Gastric adenocarcinoma of fundic gland type (chief cell predominant type): proposal for a new entity of gastric adenocarcinoma.
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| pubmed:affiliation |
Department of Human Pathology, Juntendo University School of Medicine, Tokyo, Japan.
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| pubmed:publicationType |
Journal Article
|